About Leucine-rich repeat-containing protein 70
Leucine-rich repeat-containing protein 70 (LRRC70) is a protein
from Homo sapiens identified by UniProt accession
Q7Z2Q7, 622 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 70 |
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| UniProt accession | Q7Z2Q7 |
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| Gene | LRRC70 |
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| Organism | Homo sapiens |
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| Length | 622 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.24
- diet measurement · score 0.19
- sex hormone-binding globulin measurement · score 0.16
- HOMA-IR · score 0.15
- fasting blood insulin measurement · score 0.15
- diastolic blood pressure · score 0.13
- interstitial lung disease · score 0.12
- mean corpuscular volume · score 0.10
- systolic blood pressure · score 0.07
- risk-taking behaviour · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z2Q7-F1 | alphafold | PREDICTED | 73.72 | — |
Amino-acid sequence (622 residues)
MCGLQFSLPC LRLFLVVTCY LLLLLHKEIL GCSSVCQLCT GRQINCRNLG LSSIPKNFPE STVFLYLTGN NISYINESEL TGLHSLVALY LDNSNILYVY PKAFVQLRHL YFLFLNNNFI KRLDPGIFKG LLNLRNLYLQ YNQVSFVPRG VFNDLVSVQY LNLQRNRLTV LGSGTFVGMV ALRILDLSNN NILRISESGF QHLENLACLY LGSNNLTKVP SNAFEVLKSL RRLSLSHNPI EAIQPFAFKG LANLEYLLLK NSRIRNVTRD GFSGINNLKH LILSHNDLEN LNSDTFSLLK NLIYLKLDRN RIISIDNDTF ENMGASLKIL NLSFNNLTAL HPRVLKPLSS LIHLQANSNP WECNCKLLGL RDWLASSAIT LNIYCQNPPS MRGRALRYIN ITNCVTSSIN VSRAWAVVKS PHIHHKTTAL MMAWHKVTTN GSPLENTETE NITFWERIPT SPAGRFFQEN AFGNPLETTA VLPVQIQLTT SVTLNLEKNS ALPNDAASMS GKTSLICTQE VEKLNEAFDI LLAFFILACV LIIFLIYKVV QFKQKLKASE NSRENRLEYY SFYQSARYNV TASICNTSPN SLESPGLEQI RLHKQIVPEN EAQVILFEHS AL
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