About Highly divergent homeobox
Highly divergent homeobox (HDX) is a protein
from Homo sapiens identified by UniProt accession
Q7Z353, 690 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Highly divergent homeobox |
|---|
| UniProt accession | Q7Z353 |
|---|
| Gene | HDX |
|---|
| Organism | Homo sapiens |
|---|
| Length | 690 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (12)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- serum gamma-glutamyl transferase measurement · score 0.03
- Ataxia-telangiectasia · score 0.02
- dental caries · score 0.02
- body weight · score 0.02
- dentures · score 0.02
- chronotype measurement · score 0.02
- neoplasm · score 0.01
- neuroblastoma · score 0.00
- Neurodevelopmental delay · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z353-F1 | alphafold | PREDICTED | 55.51 | — |
Amino-acid sequence (690 residues)
MNLRSVFTVE QQRILQRYYE NGMTNQSKNC FQLILQCAQE TKLDFSVVRT WVGNKRRKMS SKNSESGTAT TGTSLSAPDI TVRNVVNIAR PSSQQSSWTS ANNDVIVTGI YSPASSSSRQ GTNKHTDTQI TEAHKIPIQK TATKNDTEFQ LHIPVQRQVA HCKNASLLLG EKTIILSRQT SVLNAGNSVF NHAKKNYGNS SVQASEMTVP QKPSVCHRPC KIEPVGIQRS YKPEHTGPAL HNLCGQKPTI RDPYCRTQNL EIREVFSLAV SDYPQRILGG NAPQKPSSAE GNCLSIAMET GDAEDEYARE EELASMRAQI PSYSRFYESG SSLRAENQST TLPGPGRNMP NSQMVNIRDM SDNVLYQNRN YHLTPRTSLH TASSTMYSNT NPLRSNFSPH FASSNQLRLS QNQNNYQISG NLTVPWITGC SRKRALQDRT QFSDRDLATL KKYWDNGMTS LGSVCREKIE AVATELNVDC EIVRTWIGNR RRKYRLMGIE VPPPRGGPAD FSEQPESGSL SALTPGEEAG PEVGEDNDRN DEVSICLSEG SSQEEPNEVV PNDARAHKEE DHHAVTTDNV KIEIIDDEES DMISNSEVEQ VNSFLDYKNE EVKFIENELE IQKQKYFKLQ TFVRSLILAM KADDKEQQQA LLSDLPPELE EMDFNHASLE PDDTSFSVSS LSEKNVSESL
Explore Highly divergent homeobox with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets