About C-myc promoter-binding protein
C-myc promoter-binding protein (DENND4A) is a protein
from Homo sapiens identified by UniProt accession
Q7Z401, 1863 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | C-myc promoter-binding protein |
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| UniProt accession | Q7Z401 |
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| Gene | DENND4A |
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| Organism | Homo sapiens |
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| Length | 1863 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.27
- mean corpuscular volume · score 0.26
- mean corpuscular hemoglobin concentration · score 0.24
- erythrocyte count · score 0.20
- monocyte count · score 0.19
- body height · score 0.18
- self reported educational attainment · score 0.18
- neutrophil percentage of leukocytes · score 0.17
- monocyte percentage of leukocytes · score 0.16
- intelligence · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z401-F1 | alphafold | PREDICTED | 64.48 | — |
Amino-acid sequence (1863 residues)
MIEDKGPRVA DYFVVAGLTD VSKPLEEEIH FNDACHKVAK PKEPITDVSV IIKSLGEEVP QDYICIDVTP TGLSADLNNG SLVGPQIYLC YRRGRDKPPL TDLGVLYDWK ERLKQGCEII QSTPYGRPAN ISGSTSSQRI YITYRRASEN MTQNTLAVTD ICIIIPSKGE SPPHTFCKVD KNLNNSMWGS AVYLCYKKSV AKTNTVSYKA GLICRYPQED YESFSLPESV PLFCLPMGAT IECWPSNSKY PLPVFSTFVL TGASAEKVYG AAIQFYEPYS EENLTEKQRL LLGLTSADGK SDSSKTIHTN KCICLLSHWP FFDAFRKFLT FLYRYSISGP HVLPIEKHIS HFMHKVPFPS PQRPRILVQL SPHDNLILSQ PVSSPLPLSG GKFSTLLQNL GPENAVTLLV FAVTEHKILI HSLRPSVLTS VTEALVSMIF PFHWPCPYVP LCPLALADVL SAPCPFIVGI DSRYFDLYDP PPDVSCVDVD TNTISQIGDK KNVAWKILPK KPCKNLMNTL NNLHQQLAKL QQRPRDDGLM DLAINDYDFN SGKRLHMIDL EIQEAFLFFM ASILKGYRSY LRPITQAPSE TATDAASLFA LQAFLRSRDR SHQKFYNMMT KTQMFIRFIE ECSFVSDKDA SLAFFDDCVD KVDMDKSGEV RLIELDESFK SEHTVFVTPP EIPHLPNGEE PPLQYSYNGF PVLRNNLFER PEGFLQAKKN KLPSKSSSPN SPLPMFRRTK QEIKSAHKIA KRYSSIPQMW SRCLLRHCYG LWFICLPAYV KVCHSKVRAL KTAYDVLKKM QSKKMDPPDE VCYRILMQLC GQYDQPVLAV RVLFEMQKAG IDPNAITYGY YNKAVLESTW PSRSRSGYFL WTKVRNVVLG VTQFKRALKK HAHLSQTTLS GGQSDLGYNS LSKDEVRRGD TSTEDIQEEK DKKGSDCSSL SESESTKGSA DCLPKLSYQN SSSIVRLTGT SNNSAGKISG ESMESTPELL LISSLEDTNE TRNIQSRCFR KRHKSDNETN LQQQVVWGNR NRNLSGGVLM GFMLNRINQE ATPGDIVEKL GADAKILSNV ISKSTRPNTL DIGKPPLRSK RDSLEKESSD DDTPFDGSNY LADKVDSPVI FDLEDLDSET DVSKAGCVAT QNPKRIQRMN SSFSVKPFEK TDVATGFDPL SLLVAETEQQ QKEEEEEDED DSKSISTPSA RRDLAEEIVM YMNNMSSPLT SRTPSIDLQR ACDDKLNKKS PPLVKACRRS SLPPNSPKPV RLTKSKSYTK SEEKPRDRLW SSPAFSPTCP FREESQDTLT HSSPSFNLDT LLVPKLDVLR NSMFTAGKGV AEKASKWYSR FTMYTTSSKD QSSDRTSLSS VGAQDSESTS LTDEDVCHEL EGPISSQETS ATSGTKRIDL SRISLESSAS LEGSLSKFAL PGKSEVTSSF NASNTNIFQN YAMEVLISSC SRCRTCDCLV HDEEIMAGWT ADDSNLNTTC PFCGNIFLPF LNIEIRDLRR PGRYFLKSSP STENMHFPSS ISSQTRQSCI STSASGLDTS ALSVQGNFDL NSKSKLQENF CTRSIQIPAN RSKTAMSKCP IFPMARSIST SGPLDKEDTG RQKLISTGSL PATLQGATDS LGLEWHLPSP DPVTVPYLSP LVVWKELESL LENEGDHAIT VADFVDHHPI VFWNLVWYFR RLDLPSNLPG LILSSEHCNK YSKIPRHCMS EDSKYVLIQM LWDNMKLHQD PGQPLYILWN AHTQKYPMVH LLQKSDNSFN QELLKSMVKS IKMNDVYGPM SQILETLNKC PHFKRQRSLY REILFLSLVA LGRENIDIDA FDKEYKMAYD RLTPSQVKST HNCDRPPSTG VMECRKTFGE PYL
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