About Transmembrane channel-like protein 7
Transmembrane channel-like protein 7 (TMC7) is a protein
from Homo sapiens identified by UniProt accession
Q7Z402, 723 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Transmembrane channel-like protein 7 |
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| UniProt accession | Q7Z402 |
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| Gene | TMC7 |
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| Organism | Homo sapiens |
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| Length | 723 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.28
- psychosis predisposition measurement · score 0.20
- gut microbiome measurement · score 0.19
- Female infertility due to fertilization defect · score 0.07
- azoospermia · score 0.07
- Hydatidiform Mole · score 0.06
- female infertility due to oocyte meiotic arrest · score 0.06
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- partial chromosome Y deletion · score 0.05
- oocyte maturation defect 9 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z402-F1 | alphafold | PREDICTED | 77.39 | — |
Amino-acid sequence (723 residues)
MSESSGSALQ PGRPSRQPAV HPENLSLDSS CFSSPPVNFL QELPSYRSIA RRRTTVHSRD KQSGTLLKPT DSYSSQLEDR IAENLSSHSL RNYALNISEK RRLRDIQETQ MKYLSEWDQW KRYSSKSWKR FLEKAREMTT HLELWREDIR SIEGKFGTGI QSYFSFLRFL VLLNLVIFLI IFMLVLLPVL LTKYKITNSS FVLIPFKDMD KQCTVYPVSS SGLIYFYSYI IDLLSGTGFL EETSLFYGHY TIDGVKFQNF TYDLPLAYLL STIASLALSL LWIVKRSVEG FKINLIRSEE HFQSYCNKIF AGWDFCITNR SMADLKHSSL RYELRADLEE ERMRQKIAER TSEETIRIYS LRLFLNCIVL AVLGACFYAI YVATVFSQEH MKKEIDKMVF GENLFILYLP SIVITLANFI TPMIFAKIIR YEDYSPGFEI RLTILRCVFM RLATICVLVF TLGSKITSCD DDTCDLCGYN QKLYPCWETQ VGQEMYKLMI FDFIIILAVT LFVDFPRKLL VTYCSSCKLI QCWGQQEFAI PDNVLGIVYG QTICWIGAFF SPLLPAIATL KFIIIFYVKE WSLLYTCRPS PRPFRASNSN FFFLLVLLIG LCLAIIPLTI SISRIPSSKA CGPFTNFNTT WEVIPKTVST FPSSLQSFIH GVTSEAFAVP FFMIICLIMF YFIALAGAHK RVVIQLREQL SLESRDKCYL IQKLTEAQRD MRN
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