About Transmembrane channel-like protein 6
Transmembrane channel-like protein 6 (TMC6) is a protein
from Homo sapiens identified by UniProt accession
Q7Z403, 805 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Transmembrane channel-like protein 6 |
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| UniProt accession | Q7Z403 |
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| Gene | TMC6 |
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| Organism | Homo sapiens |
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| Length | 805 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (74)
Diseases linked to this target (Open Targets).
- epidermodysplasia verruciformis · score 0.76
- mean corpuscular volume · score 0.42
- HbA1c measurement · score 0.42
- erythrocyte count · score 0.39
- reticulocyte count · score 0.38
- mean corpuscular hemoglobin concentration · score 0.38
- mean corpuscular hemoglobin · score 0.37
- bilirubin measurement · score 0.36
- red blood cell density measurement · score 0.35
- hemoglobin measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z403-F1 | alphafold | PREDICTED | 72.31 | — |
Amino-acid sequence (805 residues)
MAQPLAFILD VPETPGDQGQ GPSPYDESEV HDSFQQLIQE QSQCTAQEGL ELQQREREVT GSSQQTLWRP EGTQSTATLR ILASMPSRTI GRSRGAIISQ YYNRTVQLRC RSSRPLLGNF VRSAWPSLRL YDLELDPTAL EEEEKQSLLV KELQSLAVAQ RDHMLRGMPL SLAEKRSLRE KSRTPRGKWR GQPGSGGVCS CCGRLRYACV LALHSLGLAL LSALQALMPW RYALKRIGGQ FGSSVLSYFL FLKTLLAFNA LLLLLLVAFI MGPQVAFPPA LPGPAPVCTG LELLTGAGCF THTVMYYGHY SNATLNQPCG SPLDGSQCTP RVGGLPYNMP LAYLSTVGVS FFITCITLVY SMAHSFGESY RVGSTSGIHA ITVFCSWDYK VTQKRASRLQ QDNIRTRLKE LLAEWQLRHS PRSVCGRLRQ AAVLGLVWLL CLGTALGCAV AVHVFSEFMI QSPEAAGQEA VLLVLPLVVG LLNLGAPYLC RVLAALEPHD SPVLEVYVAI CRNLILKLAI LGTLCYHWLG RRVGVLQGQC WEDFVGQELY RFLVMDFVLM LLDTLFGELV WRIISEKKLK RRRKPEFDIA RNVLELIYGQ TLTWLGVLFS PLLPAVQIIK LLLVFYVKKT SLLANCQAPR RPWLASHMST VFLTLLCFPA FLGAAVFLCY AVWQVKPSST CGPFRTLDTM YEAGRVWVRH LEAAGPRVSW LPWVHRYLME NTFFVFLVSA LLLAVIYLNI QVVRGQRKVI CLLKEQISNE GEDKIFLINK LHSIYERKER EERSRVGTTE EAAAPPALLT DEQDA
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