About CUB and sushi domain-containing protein 2
CUB and sushi domain-containing protein 2 (CSMD2) is a protein
from Homo sapiens identified by UniProt accession
Q7Z408, 3487 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | CUB and sushi domain-containing protein 2 |
|---|
| UniProt accession | Q7Z408 |
|---|
| Gene | CSMD2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 3487 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- body mass index · score 0.44
- fat body mass · score 0.42
- lean body mass · score 0.42
- body fat percentage · score 0.42
- body weight · score 0.39
- neurodegenerative disease · score 0.34
- waist circumference · score 0.31
- body height · score 0.30
- sleep duration · score 0.25
- grip strength measurement · score 0.21
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Amino-acid sequence (3487 residues)
MRLISIAPGP RWQVQSHHPR SAGQNCTFQL HGPNGTVESP GFPYGYPNYA NCTWTITAEE QHRIQLVFQS FALEEDFDVL SVFDGPPQPE NLRTRLTGFQ LPATIVSAAT TLSLRLISDY AVSAQGFHAT YEVLPSHTCG NPGRLPNGIQ QGSTFNLGDK VRYSCNLGFF LEGHAVLTCH AGSENSATWD FPLPSCRADD ACGGTLRGQS GIISSPHFPS EYHNNADCTW TILAELGDTI ALVFIDFQLE DGYDFLEVTG TEGSSLWFTG ASLPAPVISS KNWLRLHFTS DGNHRQRGFS AQYQVKKQIE LKSRGVKLMP SKDNSQKTSV LTQVGVSQGH NMCPDPGIPE RGKRLGSDFR LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF AAWSDHRPVC RARMCDAHLR GPSGIITSPN FPIQYDNNAH CVWIITALNP SKVIKLAFEE FDLERGYDTL TVGDGGQDGD QKTVLYILTG TSVPDLIVST NHQMWLLFQT DGSGSSLGFK ASYEEIEQGS CGDPGIPAYG RREGSRFHHG DTLKFECQPA FELVGQKAIT CQKNNQWSAK KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN HLHCVWLILA RPESRIHLAF NDIDVEPQFD FLVIKDGATA EAPVLGTFSG NQLPSSITSS GHVARLEFQT DHSTGKRGFN ITFTTFRHNE CPDPGVPVNG KRFGDSLQLG SSISFLCDEG FLGTQGSETI TCVLKEGSVV WNSAVLRCEA PCGGHLTSPS GTILSPGWPG FYKDALSCAW VIEAQPGYPI KITFDRFKTE VNYDTLEVRD GRTYSAPLIG VYHGTQVPQF LISTSNYLYL LFSTDKSHSD IGFQLRYETI TLQSDHCLDP GIPVNGQRHG NDFYVGALVT FSCDSGYTLS DGEPLECEPN FQWSRALPSC EALCGGFIQG SSGTILSPGF PDFYPNNLNC TWIIETSHGK GVFFTFHTFH LESGHDYLLI TENGSFTQPL RQLTGSRLPA PISAGLYGNF TAQVRFISDF SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR KGLQFGVGDT LTFSCFPGYR LEGTARITCL GGRRRLWSSP LPRCVAECGN SVTGTQGTLL SPNFPVNYNN NHECIYSIQT QPGKGIQLKA RAFELSEGDV LKVYDGNNNS ARLLGVFSHS EMMGVTLNST SSSLWLDFIT DAENTSKGFE LHFSSFELIK CEDPGTPKFG YKVHDEGHFA GSSVSFSCDP GYSLRGSEEL LCLSGERRTW DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA PYEHNLNCIW TIEAEAGCTI GLHFLVFDTE EVHDVLRIWD GPVESGVLLK ELSGPALPKD LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS TATSCNDPGI PQNGSRSGDS WEAGDSTVFQ CDPGYALQGS AEISCVKIEN RFFWQPSPPT CIAPCGGDLT GPSGVILSPN YPEPYPPGKE CDWKVTVSPD YVIALVFNIF NLEPGYDFLH IYDGRDSLSP LIGSFYGSQL PGRIESSSNS LFLAFRSDAS VSNAGFVIDY TENPRESCFD PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV EGTSTLSCIL GPDGKPVWNN PRPVCTAPCG GQYVGSDGVV LSPNYPQNYT SGQICLYFVT VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ HSRLLSSLSG SHTGESLPLA TSNQVLIKFS AKGLAPARGF HFVYQAVPRT SATQCSSVPE PRYGKRLGSD FSVGAIVRFE CNSGYALQGS PEIECLPVPG ALAQWNVSAP TCVVPCGGNL TERRGTILSP GFPEPYLNSL NCVWKIVVPE GAGIQIQVVS FVTEQNWDSL EVFDGADNTV TMLGSFSGTT VPALLNSTSN QLYLHFYSDI SVSAAGFHLE YKTVGLSSCP EPAVPSNGVK TGERYLVNDV VSFQCEPGYA LQGHAHISCM PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL SPGFPGNYPS NMDCSWKIAL PVGFGAHIQF LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG SELPSSLLST SHETTVYFHS DHSQNRPGFK LEYQDLTYSH QISSFLRGFD LSELERTNST PPVAASYVWD LDPGCEAYEL QECPDPEPFA NGIVRGAGYN VGQSVTFECL PGYQLTGHPV LTCQHGTNRN WDHPLPKCEV PCGGNITSSN GTVYSPGFPS PYSSSQDCVW LITVPIGHGV RLNLSLLQTE PSGDFITIWD GPQQTAPRLG VFTRSMAKKT VQSSSNQVLL KFHRDAATGG IFAIAFSAYP LTKCPPPTIL PNAEVVTENE EFNIGDIVRY RCLPGFTLVG NEILTCKLGT YLQFEGPPPI CEVHCPTNEL LTDSTGVILS QSYPGSYPQF QTCSWLVRVE PDYNISLTVE YFLSEKQYDE FEIFDGPSGQ SPLLKALSGN YSAPLIVTSS SNSVYLRWSS DHAYNRKGFK IRYSAPYCSL PRAPLHGFIL GQTSTQPGGS IHFGCNAGYR LVGHSMAICT RHPQGYHLWS EAIPLCQALS CGLPEAPKNG MVFGKEYTVG TKAMYSCSEG YHLQAGAEAT AECLDTGLWS NRNVPPQCVP VTCPDVSSIS VEHGRWRLIF ETQYQFQAQL MLICDPGYYY TGQRVIRCQA NGKWSLGDST PTCRIISCGE LPIPPNGHRI GTLSVYGATA IFSCNSGYTL VGSRVRECMA NGLWSGSEVR CLAGHCGTPE PIVNGHINGE NYSYRGSVVY QCNAGFRLIG MSVRICQQDH HWSGKTPFCV LVSCGHPGSP PHSQMSGDSY TVGAVVRYSC IGKRTLVGNS TRMCGLDGHW TGSLPHCSGT SVGVCGDPGI PAHGIRLGDS FDPGTVMRFS CEAGHVLRGS SERTCQANGS WSGSQPECGV ISCGNPGTPS NARVVFSDGL VFSSSIVYEC REGYYATGLL SRHCSVNGTW TGSDPECLVI NCGDPGIPAN GLRLGNDFRY NKTVTYQCVP GYMMESHRVS VLSCTKDRTW NGTKPVCKAL MCKPPPLIPN GKVVGSDFMW GSSVTYACLE GYQLSLPAVF TCEGNGSWTG ELPQCFPVFC GDPGVPSRGR REDRGFSYRS SVSFSCHPPL VLVGSPRRFC QSDGTWSGTQ PSCIDPTLTT CADPGVPQFG IQNNSQGYQV GSTVLFRCQK GYLLQGSTTR TCLPNLTWSG TPPDCVPHHC RQPETPTHAN VGALDLPSMG YTLIYSCQEG FSLKGGSEHR TCKADGSWTG KPPICLEVRP SGRPINTARE PPLTQALIPG DVFAKNSLWK GAYEYQGKKQ PAMLRVTGFQ VANSKVNATM IDHSGVELHL AGTYKKEDFH LLLQVYQITG PVEIFMNKFK DDHWALDGHV SSESSGATFI YQGSVKGQGF GQFGFQRLDL RLLESDPESI GRHFASNSSS VAAAILVPFI ALIIAGFVLY LYKHRRRPKV PFNGYAGHEN TNVRATFENP MYDRNIQPTD IMASEAEFTV STVCTAV
Explore CUB and sushi domain-containing protein 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets