E3 ubiquitin-protein ligase RNF144B (RNF144B)

About E3 ubiquitin-protein ligase RNF144B

E3 ubiquitin-protein ligase RNF144B (RNF144B) is a protein from Homo sapiens identified by UniProt accession Q7Z419, 303 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase RNF144B
UniProt accession	Q7Z419
Gene	RNF144B
Organism	Homo sapiens
Length	303 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.45
grip strength measurement · score 0.40
body mass index · score 0.38
body height · score 0.38
thiopurine methyltransferase activity measurement · score 0.34
PHF-tau measurement · score 0.33
calcific tendinitis · score 0.33
osteoarthritis, hand · score 0.32
serum urea measurement · score 0.31
atrial flutter · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z419-F1	alphafold	PREDICTED	82.30	—

Amino-acid sequence (303 residues)

MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW CPVADCQTVC PVASSDPGQP VLVECPSCHL KFCSCCKDAW HAEVSCRDSQ PIVLPTEHRA LFGTDAEAPI KQCPVCRVYI ERNEGCAQMM CKNCKHTFCW YCLQNLDNDI FLRHYDKGPC RNKLGHSRAS VMWNRTQVVG ILVGLGIIAL VTSPLLLLAS PCIICCVCKS CRGKKKKHDP STT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards