Protein lifeguard 1 (GRINA)

About Protein lifeguard 1

Protein lifeguard 1 (GRINA) is a protein from Homo sapiens identified by UniProt accession Q7Z429, 371 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Protein lifeguard 1
UniProt accession	Q7Z429
Gene	GRINA
Organism	Homo sapiens
Length	371 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.16
mean corpuscular volume · score 0.15
Red cell distribution width · score 0.14
low density lipoprotein cholesterol measurement · score 0.14
total cholesterol measurement · score 0.13
apolipoprotein B measurement · score 0.12
leukocyte count · score 0.12
fibrinogen measurement · score 0.11
IGF-1 measurement · score 0.10
serum albumin measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z429-F1	alphafold	PREDICTED	71.74	—

Amino-acid sequence (371 residues)

MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS PYGQPGYPHG PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPQVF PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV SVFTFVAEVK GFVRENVWTY YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY MVGMIASFYN TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN LYTDIINIFL YILTIIGRAK E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards