About Polycystin-1-like protein 3
Polycystin-1-like protein 3 (PKD1L3) is a protein
from Homo sapiens identified by UniProt accession
Q7Z443, 1732 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Polycystin-1-like protein 3 |
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| UniProt accession | Q7Z443 |
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| Gene | PKD1L3 |
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| Organism | Homo sapiens |
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| Length | 1732 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.30
- total cholesterol measurement · score 0.24
- intelligence · score 0.21
- self reported educational attainment · score 0.21
- gut microbiome measurement · score 0.21
- urate measurement · score 0.20
- neurodegenerative disease · score 0.20
- fibrinogen measurement · score 0.18
- grip strength measurement · score 0.18
- alkaline phosphatase measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z443-F1 | alphafold | PREDICTED | 64.84 | — |
Amino-acid sequence (1732 residues)
MFFKGGSWLW LYIRTSIILG SELNSPAPHG QNNCYQLNRF QCSFEEAQHY CHVQRGFLAH IWNKEVQDLI RDYLEEGKKW WIGQNVMPLK KHQDNKYPAD VAANGPPKPL SCTYLSRNFI RISSKGDKCL LKYYFICQTG DFLDGDAHYE RNGNNSHLYQ RHKKTKRGVA IARDKMPPGP GHLPTTCHYP LPAHLSKTLC HPISQFPSVL SSITSQVTSA ASEPSSQPLP VITQLTMPVS VTHAGQSLAE TTSSPKEEGH PNTFTSYLQV SLQKASGQVI DEIAGNFSRA VHGLQALNKL QEACEFLQKL TALTPRFSKP AQVNLINSLI YLSEELLRIP FQNNNSLGFK VPPTVCPFHS LNNVTKAGEG SWLESKRHTE PVEDILEMSL VEFGNIGEAF LEQNQSPESS VTLTSANATL LLSRQNISTL PLSSYTLGHP APVRLGFPSA LALKELLNKH PGVNVQITGL AFNPFKDLDN RNIVGSIGSV LLSANRKLLQ VHDLMEDIEI MLWRNVSLET HPTSLNMSTH QLTITVNVTS LEKSLIVSID PDSPLLMTLY LGFQYQPNCT HFHLNITLPK DKVWQKDEEY TWVLNPEHLQ HGIGTYYITA VLSERQEGAQ QTPSLVSVIT AVTQCYYWEI HNQTWSSAGC QVGPQSTILR TQCLCNHLTF FASDFFVVPR TVNVEDTIKL FLRVTNNPVG VSLLASLLGF YVITVVWARK KDQADMQKVK VTVLADNDPS AQFHYLIQVY TGYRRSAATT AKVVITLYGS EGRSEPHHLC DPQKTVFERG GLDVFLLTTW TSLGNLHSLR LWHDNSGVSP SWYVSQVIVC DMAVKRKWHF LCNCWLAVDL GDCELDRVFI PVSKRELFSF RHLFSSMIVE KFTQDYLWLS IATRHPWNQF TRVQRLSCCM TLLLCNMVIN VMFWKINSTT AKRDEQMRPF AVAWSELLVS IHTAVILFPI NLVIGRLFPL IEPQETLPLF PPIQASCLSD ASVEPLSATM VVEELKETVR FLLRRNTYLL SKCEQPPWSS WDITKLVKLL SSLVSSHLEG QGCHQQGERH WARVVPENHH HFCCYLHRVL QRLKSHLGTL GLTQGHQSCD FLDAASQLQK LQELLETHIL PTEQEPSREV TSFAILSSEE GKKPISNGLS KWLTSVCWLL LGFTSLASAF FTALYSLELS KDQATSWMIS IILSVLQNIF ISQPVKVVFF TFLYSLMMSR MPRLNKENEQ QTKRILALLA KCSSSVPGSR DKNNPVYVAP AINSPTKHPE RTLKKKKLFK LTGDILVQIL FLTLLMTAIY SAKNSNRFYL HQAIWKTFSH QFSEIKLLQD FYPWANHILL PSLYGDYRGK NAVLEPSHCK CGVQLIFQIP RTKTYEKVDE GQLAFCDNGH TCGRPKSLFP GLHLRRFSYI CSPRPMVLIP TDELHERLTS KNENGFSYIM RGAFFTSLRL ESFTSLQMSK KGCVWSIISQ VIYYLLVCYY AFIQGCQLKQ QKWRFFTGKR NILDTSIILI SFILLGLDMK SISLHKKNMA RYRDDQDRFI SFYEAVKVNS AATHLVGFPV LLATVQLWNL LRHSPRLRVI SRTLSRAWDE VVGFLLIILI LLTGYAIAFN LLFGCSISDY RTFFSSAVTV VGLLMGISHQ EEVFALDPVL GTFLILTSVI LMVLVVINLF VSAILMAFGK ERKSLKKEAA LIDTLLQKLS NLLGISWPQK TSSEQAATTA VGSDTEVLDE LP
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