Cytochrome P450 2U1 (CYP2U1)

About Cytochrome P450 2U1

Cytochrome P450 2U1 (CYP2U1) is a protein from Homo sapiens identified by UniProt accession Q7Z449, 544 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	Cytochrome P450 2U1
UniProt accession	Q7Z449
Gene	CYP2U1
Organism	Homo sapiens
Length	544 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

Autosomal recessive spastic paraplegia type 56 · score 0.79
hereditary spastic paraplegia 56 · score 0.75
hereditary spastic paraplegia · score 0.68
Spastic paraplegia · score 0.55
genetic disorder · score 0.41
Intellectual disability · score 0.33
Seizure · score 0.33
Lower limb spasticity · score 0.33
diastolic blood pressure · score 0.29
Abnormality of the nervous system · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z449-F1	alphafold	PREDICTED	88.15	—

Amino-acid sequence (544 residues)

MSSPGPSQPP AEDPPWPARL LRAPLGLLRL DPSGGALLLC GLVALLGWSW LRRRRARGIP PGPTPWPLVG NFGHVLLPPF LRRRSWLSSR TRAAGIDPSV IGPQVLLAHL ARVYGSIFSF FIGHYLVVVL SDFHSVREAL VQQAEVFSDR PRVPLISIVT KEKGVVFAHY GPVWRQQRKF SHSTLRHFGL GKLSLEPKII EEFKYVKAEM QKHGEDPFCP FSIISNAVSN IICSLCFGQR FDYTNSEFKK MLGFMSRGLE ICLNSQVLLV NICPWLYYLP FGPFKELRQI EKDITSFLKK IIKDHQESLD RENPQDFIDM YLLHMEEERK NNSNSSFDEE YLFYIIGDLF IAGTDTTTNS LLWCLLYMSL NPDVQEKVHE EIERVIGANR APSLTDKAQM PYTEATIMEV QRLTVVVPLA IPHMTSENTV LQGYTIPKGT LILPNLWSVH RDPAIWEKPE DFYPNRFLDD QGQLIKKETF IPFGIGKRVC MGEQLAKMEL FLMFVSLMQS FAFALPEDSK KPLLTGRFGL TLAPHPFNIT ISRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards