About Microtubule organization protein AKNA
Microtubule organization protein AKNA (AKNA) is a protein
from Homo sapiens identified by UniProt accession
Q7Z591, 1439 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Microtubule organization protein AKNA |
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| UniProt accession | Q7Z591 |
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| Gene | AKNA |
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| Organism | Homo sapiens |
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| Length | 1439 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (102)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.46
- aspartate aminotransferase measurement · score 0.43
- high density lipoprotein cholesterol measurement · score 0.41
- apolipoprotein A 1 measurement · score 0.41
- sex hormone-binding globulin measurement · score 0.40
- total cholesterol measurement · score 0.32
- low density lipoprotein cholesterol measurement · score 0.22
- non-alcoholic fatty liver disease · score 0.19
- testosterone measurement · score 0.17
- platelet count · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z591-F1 | alphafold | PREDICTED | 46.80 | — |
Amino-acid sequence (1439 residues)
MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA TSPELLEDFR LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS PASSHEPLAW LPQQGRQLDM TEEEPDGTLG SLEVEEAGES SSRLGYEAGL SLEGHGNTSP MALGHGQARG WVASGEQASG DKLSEHSEVN PSVELSPARS WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS HHLLSPDGRT GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG RGQLNYPLPD FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP AEIVQEVLLS SGEAALAKDT PPAHPITRVP QEFQTPEQAT ELVHQLQEDY HRLLTKYAEA ENTIDQLRLG AKVNLFSDPP QPNHSIHTGM VPQGTKVLSF TIPQPRSAEW WPGPAEDPQA SAASGWPSAR GDLSPSSLTS MPTLGWLPEN RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS CLEELKEHID QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP AIKTSCPEPA TTTAAASTGP CPLHVNVEVS SGNSEVEDRP QDPLARLRHK ELQMEQVYHG LMERYLSVKS LPEAMRMEEE EEGEEEEEEE GGGDSLEVDG VAATPGKAEA TRVLPRQCPV QAEKSHGAPL EEATEKMVSM KPPGFQASLA RDGHMSGLGK AEAAPPGPGV PPHPPGTKSA ASHQSSMTSL EGSGISERLP QKPLHRGGGP HLEETWMASP ETDSGFVGSE TSRVSPLTQT PEHRLSHIST AGTLAQPFAA SVPRDGASYP KARGSLIPRR ATEPSTPRSQ AQRYLSSPSG PLRQRAPNFS LERTLAAEMA VPGSEFEGHK RISEQPLPNK TISPPPAPAP AAAPLPCGPT ETIPSFLLTR AGRDQAICEL QEEVSRLRLR LEDSLHQPLQ GSPTRPASAF DRPARTRGRP ADSPATWGSH YGSKSTERLP GEPRGEEQIV PPGRQRARSS SVPREVLRLS LSSESELPSL PLFSEKSKTT KDSPQAARDG KRGVGSAGWP DRVTFRGQYT GHEYHVLSPK AVPKGNGTVS CPHCRPIRTQ DAGGAVTGDP LGPPPADTLQ CPLCGQVGSP PEADGPGSAT SGAEKATTRR KASSTPSPKQ RSKQAGSSPR PPPGLWYLAT APPAPAPPAF AYISSVPIMP YPPAAVYYAP AGPTSAQPAA KWPPTASPPP ARRHRHSIQL DLGDLEELNK ALSRAVQAAE SVRSTTRQMR SSLSADLRQA HSLRGSCLF
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