17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13)

About 17-beta-hydroxysteroid dehydrogenase 13

17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) is a protein from Homo sapiens identified by UniProt accession Q7Z5P4, 300 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.

Target properties

Protein name	17-beta-hydroxysteroid dehydrogenase 13
UniProt accession	Q7Z5P4
Gene	HSD17B13
Organism	Homo sapiens
Length	300 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (121)

Diseases linked to this target (Open Targets).

serum alanine aminotransferase measurement · score 0.51
aspartate aminotransferase measurement · score 0.50
sex hormone-binding globulin measurement · score 0.47
platelet count · score 0.46
testosterone measurement · score 0.44
triglyceride measurement · score 0.41
protein measurement · score 0.39
serum gamma-glutamyl transferase measurement · score 0.37
cirrhosis of liver · score 0.34
non-alcoholic fatty liver disease · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z5P4-F1	alphafold	PREDICTED	94.01	—

Amino-acid sequence (300 residues)

MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR QTTYEFAKRQ SILVLWDINK RGVEETAAEC RKLGVTAHAY VVDCSNREEI YRSLNQVKKE VGDVTIVVNN AGTVYPADLL STKDEEITKT FEVNILGHFW ITKALLPSMM ERNHGHIVTV ASVCGHEGIP YLIPYCSSKF AAVGFHRGLT SELQALGKTG IKTSCLCPVF VNTGFTKNPS TRLWPVLETD EVVRSLIDGI LTNKKMIFVP SYINIFLRLQ KFLPERASAI LNRMQNIQFE AVVGHKIKMK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards