WD repeat-containing protein 53 (WDR53)

About WD repeat-containing protein 53

WD repeat-containing protein 53 (WDR53) is a protein from Homo sapiens identified by UniProt accession Q7Z5U6, 358 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	WD repeat-containing protein 53
UniProt accession	Q7Z5U6
Gene	WDR53
Organism	Homo sapiens
Length	358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.09
mouth mucosa disorder · score 0.08
lip disorder · score 0.08
velopharyngeal dysfunction · score 0.08
mean reticulocyte volume · score 0.08
gut microbiome measurement · score 0.08
self reported educational attainment · score 0.06
Rh deficiency syndrome · score 0.06
dehydrated hereditary stomatocytosis · score 0.05
gluthathione peroxidase deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z5U6-F1	alphafold	PREDICTED	85.40	—

Amino-acid sequence (358 residues)

MAVKWTGGHS SPVLCLNASK EGLLASGAEG GDLTAWGEDG TPLGHTRFQG ADDVTSVLFS PSCPTKLYAS HGETISVLDV RSLKDSLDHF HVNEEEINCL SLNQTENLLA SADDSGAIKI LDLENKKVIR SLKRHSNICS SVAFRPQRPQ SLVSCGLDMQ VMLWSLQKAR PLWITNLQED ETEEMEGPQS PGQLLNPALA HSISVASCGN IFSCGAEDGK VRIFRVMGVK CEQELGFKGH TSGVSQVCFL PESYLLLTGG NDGKITLWDA NSEVEKKQKS PTKRTHRKKP KRGTCTKQGG NTNASVTDEE EHGNILPKLN IEHGEKVNWL LGTKIKGHQN ILVADQTSCI SVYPLNEF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards