About G protein-coupled receptor 142
G protein-coupled receptor 142 (GPR142) is a protein
from Homo sapiens identified by UniProt accession
Q7Z601, 462 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | G protein-coupled receptor 142 |
|---|
| UniProt accession | Q7Z601 |
|---|
| Gene | GPR142 |
|---|
| Organism | Homo sapiens |
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| Length | 462 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- MODY · score 0.07
- hyperinsulinism due to INSR deficiency · score 0.06
- hyperinsulinism due to glucokinase deficiency · score 0.06
- hemoglobin D disease · score 0.06
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
- dominant beta-thalassemia · score 0.05
- exercise-induced hyperinsulinism · score 0.05
- hemoglobin C-beta-thalassemia syndrome · score 0.05
- hemoglobin H disease · score 0.05
- hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z601-F1 | alphafold | PREDICTED | 63.66 | — |
Amino-acid sequence (462 residues)
MSIMMLPMEQ KIQWVPTSLQ DITAVLGTEA YTEEDKSMVS HAQKSQHSCL SHSRWLRSPQ VTGGSWDLRI RPSKDSSSFR QAQCLRKDPG ANNHLESQGV RGTAGDADRE LRGPSEKATA GQPRVTLLPT PHVSGLSQEF ESHWPEIAER SPCVAGVIPV IYYSVLLGLG LPVSLLTAVA LARLATRTRR PSYYYLLALT ASDIIIQVVI VFAGFLLQGA VLARQVPQAV VRTANILEFA ANHASVWIAI LLTVDRYTAL CHPLHHRAAS SPGRTRRAIA AVLSAALLTG IPFYWWLDMW RDTDSPRTLD EVLKWAHCLT VYFIPCGVFL VTNSAIIHRL RRRGRSGLQP RVGKSTAILL GITTLFTLLW APRVFVMLYH MYVAPVHRDW RVHLALDVAN MVAMLHTAAN FGLYCFVSKT FRATVRQVIH DAYLPCTLAS QPEGMAAKPV MEPPGLPTGA EV
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