Probable G-protein coupled receptor 141 (GPR141)

About Probable G-protein coupled receptor 141

Probable G-protein coupled receptor 141 (GPR141) is a protein from Homo sapiens identified by UniProt accession Q7Z602, 305 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 141
UniProt accession	Q7Z602
Gene	GPR141
Organism	Homo sapiens
Length	305 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (15)

Diseases linked to this target (Open Targets).

neoplasm · score 0.05
neurofibrillary tangles measurement · score 0.03
PHF-tau measurement · score 0.02
breast carcinoma · score 0.01
triple-negative breast cancer · score 0.01
cancer · score 0.01
Crohn's disease · score 0.01
ulcerative colitis · score 0.00
experimental autoimmune encephalomyelitis · score 0.00
invasive breast ductal carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q7Z602-F1	alphafold	PREDICTED	81.60	—

Amino-acid sequence (305 residues)

MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV TTMAVINLVV VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY LTFLFYVVIL VTRYLIFFKC KDKVEFYRKL HAVAASAGMW TLVIVIVVPL VVSRYGIHEE YNEEHCFKFH KELAYTYVKI INYMIVIFVI AVAVILLVFQ VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP YQFFRIYYLN VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN CVLCR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards