About Uncharacterized aarF domain-containing protein kinase 2
Uncharacterized aarF domain-containing protein kinase 2 (ADCK2) is a protein
from Homo sapiens identified by UniProt accession
Q7Z695, 626 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Uncharacterized aarF domain-containing protein kinase 2 |
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| UniProt accession | Q7Z695 |
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| Gene | ADCK2 |
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| Organism | Homo sapiens |
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| Length | 626 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- body height · score 0.08
- non-small cell lung carcinoma · score 0.07
- melanoma · score 0.07
- sitting height measurement · score 0.07
- appendicular lean mass · score 0.05
- attention deficit hyperactivity disorder · score 0.05
- vital capacity · score 0.05
- Tourette syndrome · score 0.05
- attention deficit-hyperactivity disorder 8 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z695-F1 | alphafold | PREDICTED | 71.38 | — |
Amino-acid sequence (626 residues)
MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV VSLCGDVGEG APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW LRAGALLVKF FPLLLLYPLT YLAPSVSTLW LHLLLKATET SGPTYIKLGQ WASTRRDLFS EAFCAQFSKL HVRVTPHPWT HTERFLRQAF GDDWGSILSF ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP FSHTGAVGGL RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV EEFEKLMVQQ IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE TYEESVPVSS YQQAGIPVDL KRKIARLGIN MLLKMIFVDN FVHADLHPGN ILVQGANGLS SSQEAQLQQA DICDTLVVAV PSSLCPLRLV LLDAGIVAEL QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE GFKTEMAMLV TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL GRSLDPKLDI LEAARPFLLT GPVCPP
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