About Sprouty-related, EVH1 domain-containing protein 1
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) is a protein
from Homo sapiens identified by UniProt accession
Q7Z699, 444 residues long.
MolForge cross-references it against 0 known binders and
169 disease associations.
Target properties
| Protein name | Sprouty-related, EVH1 domain-containing protein 1 |
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| UniProt accession | Q7Z699 |
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| Gene | SPRED1 |
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| Organism | Homo sapiens |
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| Length | 444 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (169)
Diseases linked to this target (Open Targets).
- Legius syndrome · score 0.82
- Abnormality of the cardiovascular system · score 0.53
- Noonan syndrome and Noonan-related syndrome · score 0.53
- body height · score 0.45
- lean body mass · score 0.44
- genetic disorder · score 0.41
- appendicular lean mass · score 0.40
- neurofibromatosis-Noonan syndrome · score 0.40
- birth weight · score 0.39
- cancer · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q7Z699-F1 | alphafold | PREDICTED | 63.76 | — |
Amino-acid sequence (444 residues)
MSEETATSDN DNSYARVRAV VMTRDDSSGG WLPLGGSGLS SVTVFKVPHQ EENGCADFFI RGERLRDKMV VLECMLKKDL IYNKVTPTFH HWKIDDKKFG LTFQSPADAR AFDRGIRRAI EDISQGCPES KNEAEGADDL QANEEDSSSS LVKDHLFQQE TVVTSEPYRS SNIRPSPFED LNARRVYMQS QANQITFGQP GLDIQSRSME YVQRQISKEC GSLKSQNRVP LKSIRHVSFQ DEDEIVRINP RDILIRRYAD YRHPDMWKND LERDDADSSI QFSKPDSKKS DYLYSCGDET KLSSPKDSVV FKTQPSSLKI KKSKRRKEDG ERSRCVYCQE RFNHEENVRG KCQDAPDPIK RCIYQVSCML CAESMLYHCM SDSEGDFSDP CSCDTSDDKF CLRWLALVAL SFIVPCMCCY VPLRMCHRCG EACGCCGGKH KAAG
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