About Nucleoplasmin-2
Nucleoplasmin-2 (NPM2) is a protein
from Homo sapiens identified by UniProt accession
Q86SE8, 214 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Nucleoplasmin-2 |
|---|
| UniProt accession | Q86SE8 |
|---|
| Gene | NPM2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 214 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- cerebrospinal fluid biomarker measurement · score 0.26
- mean corpuscular volume · score 0.09
- body height · score 0.07
- calcium measurement · score 0.06
- malignant pleural mesothelioma · score 0.06
- melanoma · score 0.05
- serum gamma-glutamyl transferase measurement · score 0.05
- atrial fibrillation · score 0.05
- central nervous system cancer · score 0.04
- mean corpuscular hemoglobin concentration · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86SE8-F1 | alphafold | PREDICTED | 73.55 | — |
Amino-acid sequence (214 residues)
MNLSSASSTE EKAVTTVLWG CELSQERRTW TFRPQLEGKQ SCRLLLHTIC LGEKAKEEMH RVEILPPANQ EDKKMQPVTI ASLQASVLPM VSMVGVQLSP PVTFQLRAGS GPVFLSGQER YEASDLTWEE EEEEEGEEEE EEEEDDEDED ADISLEEQSP VKQVKRLVPQ KQASVAKKKK LEKEEEEIRA SVRDKSPVKK AKATARAKKP GFKK
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