Zygote arrest protein 1 (ZAR1)

About Zygote arrest protein 1

Zygote arrest protein 1 (ZAR1) is a protein from Homo sapiens identified by UniProt accession Q86SH2, 424 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Zygote arrest protein 1
UniProt accession	Q86SH2
Gene	ZAR1
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.39
mean platelet volume · score 0.38
hemoglobin measurement · score 0.34
pulse pressure measurement · score 0.34
body height · score 0.24
hematocrit · score 0.24
metabolite measurement · score 0.16
platelet count · score 0.15
mean corpuscular volume · score 0.13
age at menopause · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86SH2-F1	alphafold	PREDICTED	54.45	—

Amino-acid sequence (424 residues)

MAALGDEVLD GYVFPACPPC SYRYPYPAAT KGKGAAGGSW QQRGRGCLPA SSPCSAGAAS LSFPGCGRLT AAEYFDSYQR ERLMALLAQV GPGLGPRARR AGSCDVAVQV SPRIDAAVQC SLGRRTLQRR ARDPESPAGP GAEGTTGGGS FSQQPSRRGL EQGSPQNGAP RPMRFPRTVA VYSPLALRRL TAFLEGPGPA AGEQRSGASD GERGPPPARL QGPEEGEVWT KKAPRRPQSD DDGEAQAAVR ASWEQPADGP ELPPREAQEG EAAPRSALRS PGQPPSAGRA RDGGDGREAA VAGEGPSPRS PELGKERLRF QFLEQKYGYY HCKDCNIRWE SAYVWCVQGT NKVYFKQFCR TCQKSYNPYR VEDITCQSCK QTRCSCPVKL RHVDPKRPHR QDLCGRCKGK RLSCDSTFSF KYII

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards