Amphoterin-induced protein 2 (AMIGO2)

About Amphoterin-induced protein 2

Amphoterin-induced protein 2 (AMIGO2) is a protein from Homo sapiens identified by UniProt accession Q86SJ2, 522 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

Target properties

Protein name	Amphoterin-induced protein 2
UniProt accession	Q86SJ2
Gene	AMIGO2
Organism	Homo sapiens
Length	522 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (96)

Diseases linked to this target (Open Targets).

chemotherapy-induced cytotoxicity measurement · score 0.34
sex interaction measurement · score 0.25
omega-3 polyunsaturated fatty acid measurement · score 0.25
PHF-tau measurement · score 0.11
cancer · score 0.10
skin pigmentation · score 0.08
neoplasm · score 0.08
urinary bladder carcinoma · score 0.07
gonorrhea · score 0.07
breast cancer · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86SJ2-F1	alphafold	PREDICTED	75.09	—

Amino-acid sequence (522 residues)

MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD IVSCTNKNLS KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL RHNNITSIST GSFSTTPNLK CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN NHISYLDPSA FGGLSQLQKL YLSGNFLTQF PMDLYVGRFK LAELMFLDVS YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL VFWYRRHFSS VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI ESPRFEDAGV YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF TTLAACVASI VLVLLYLYLT PCPCKCKTKR QKNMLHQSNA HSSILSPGPA SDASADERKA GAGKRVVFLE PLKDTAAGQN GKVRLFPSEA VIAEGILKST RGKSDSDSVN SVFSDTPFVA ST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards