About Probable G-protein coupled receptor 149
Probable G-protein coupled receptor 149 (GPR149) is a protein
from Homo sapiens identified by UniProt accession
Q86SP6, 731 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Probable G-protein coupled receptor 149 |
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| UniProt accession | Q86SP6 |
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| Gene | GPR149 |
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| Organism | Homo sapiens |
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| Length | 731 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- Headache · score 0.31
- migraine disorder · score 0.22
- coronary artery disease · score 0.12
- hypertrophic cardiomyopathy · score 0.11
- high density lipoprotein cholesterol measurement · score 0.11
- lean body mass · score 0.10
- apolipoprotein A 1 measurement · score 0.10
- cystatin C measurement · score 0.09
- fat body mass · score 0.09
- myocardial infarction · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86SP6-F1 | alphafold | PREDICTED | 53.96 | — |
Amino-acid sequence (731 residues)
MSLFLSNLST NDSSLWKENH NSTDLLNPPG TLNIYLFCLT CLMTFAALVG SIYSLISLLK MQNRTVVSML VASWSVDDLM SVLSVTIFMF LQWPNEVPGY FQFLCTTSAL MYLCQGLSSN LKATLLVSYN FYTMHRGVGS QTASRRSGQV LGVVLTVWAA SLLLSALPLC GWGAFVRTPW GCLVDCSSSY VLFLSIVYAL AFGLLVGLSV PLTHRLLCSE EPPRLHSNYQ EISRGASIPG TPPTAGRVVS LSPEDAPGPS LRRSGGCSPS SDTVFGPGAP AAAGAEACRR ENRGTLYGTR SFTVSVAQKR FALILALTKV VLWLPMMMHM VVQNVVGFQS LPLETFSFLL TLLATTVTPV FVLSKRWTHL PCGCIINCRQ NAYAVASDGK KIKRKGFEFN LSFQKSYGIY KIAHEDYYDD DENSIFYHNL MNSECETTKD PQRDNRNIFN AIKVEISTTP SLDSSTQRGI NKCTNTDITE AKQDSNNKKD AFSDKTGGDI NYEETTFSEG PERRLSHEES QKPDLSDWEW CRSKSERTPR QRSGYALAIP LCAFQGTVSL HAPTGKTLSL STYEVSAEGQ KITPASKKIE VYRSKSVGHE PNSEDSSSTF VDTSVKIHLE VLEICDNEEA LDTVSIISNI SQSSTQVRSP SLRYSRKENR FVSCDLGETA SYSLFLPTSN PDGDINISIP DTVEAHRQNS KRQHQERDGY QEEIQLLNKA YRKREEESKG S
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