About Pleckstrin homology-like domain family B member 2
Pleckstrin homology-like domain family B member 2 (PHLDB2) is a protein
from Homo sapiens identified by UniProt accession
Q86SQ0, 1253 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Pleckstrin homology-like domain family B member 2 |
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| UniProt accession | Q86SQ0 |
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| Gene | PHLDB2 |
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| Organism | Homo sapiens |
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| Length | 1253 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (62)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.41
- atrial fibrillation · score 0.38
- lobe attachment · score 0.33
- lacrimal apparatus disease · score 0.31
- eyelid disease · score 0.31
- hemorrhoid · score 0.27
- peak expiratory flow · score 0.18
- PR interval · score 0.17
- FEV/FVC ratio · score 0.14
- atrial flutter · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86SQ0-F1 | alphafold | PREDICTED | 58.13 | — |
Amino-acid sequence (1253 residues)
MEEHSYIQKE LDLQNGSLEE DSVVHSVEND SQNMMESLSP KKYSSSLRFK ANGDYSGSYL TLSQPVPAKR SPSPLGTSVR SSPSLAKIQG SKQFSYDGTD KNIPMKPPTP LLNTTSSLSG YPLGRADFDH YTGRDSERAL RLSEKPPYSK YSSRHKSHDN VYSLGGLEGR KASGSLLAMW NGSSLSDAGP PPISRSGAAS MPSSPKQARK MSIQDSLALQ PKLTRHKELA SENINLRTRK YSSSSLSHMG AYSRSLPRLY RATENQLTPL SLPPRNSLGN SKRTKLGEKD LPHSVIDNDN YLNFSSLSSG ALPYKTSASE GNPYVSSTLS VPASPRVARK MLLASTSSCA SDDFDQASYV GTNPSHSLLA GESDRVFATR RNFSCGSVEF DEADLESLRQ ASGTPQPALR ERKSSISSIS GRDDLMDYHR RQREERLREQ EMERLERQRL ETILSLCAEY TKPDSRLSTG TTVEDVQKIN KELEKLQLSD EESVFEEALM SPDTRYRCHR KDSLPDADLA SCGSLSQSSA SFFTPRSTRN DELLSDLTRT PPPPSSTFPK ASSESSYLSI LPKTPEGISE EQRSQELAAM EETRIVILNN LEELKQKIKD INDQMDESFR ELDMECALLD GEQKSETTEL MKEKEILDHL NRKIAELEKN IVGEKTKEKV KLDAEREKLE RLQELYSEQK TQLDNCPESM REQLQQQLKR DADLLDVESK HFEDLEFQQL EHESRLDEEK ENLTQQLLRE VAEYQRNIVS RKEKISALKK QANHIVQQAQ REQDHFVKEK NNLIMMLQRE KENLCNLEKK YSSLSGGKGF PVNPNTLKEG YISVNEINEP CGNSTNLSPS TQFPADADAV ATEPATAVLA SQPQSKEHFR SLEERKKQHK EGLYLSDTLP RKKTTSSISP HFSSATMGRS ITPKAHLPLG QSNSCGSVLP PSLAAMAKDS ESRRMLRGYN HQQMSEGHRQ KSEFYNRTAS ESNVYLNSFH YPDHSYKDQA FDTLSLDSSD SMETSISACS PDNISSASTS NIARIEEMER LLKQAHAEKT RLLESREREM EAKKRALEEE KRRREILEKR LQEETSQRQK LIEKEVKIRE RQRAQARPLT RYLPVRKEDF DLRSHVETAG HNIDTCYHVS ITEKTCRGFL IKMGGKIKTW KKRWFVFDRN KRTFSYYADK HETKLKGVIY FQAIEEVYYD HLKNANKSPN PLLTFSVKTH DRIYYMVAPS PEAMRIWMDV IVTGAEGYTH FLL
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