About Dehydrodolichyl diphosphate synthase complex subunit DHDDS
Dehydrodolichyl diphosphate synthase complex subunit DHDDS (DHDDS) is a protein
from Homo sapiens identified by UniProt accession
Q86SQ9, 333 residues long.
MolForge cross-references it against 0 known binders and
142 disease associations.
Target properties
| Protein name | Dehydrodolichyl diphosphate synthase complex subunit DHDDS |
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| UniProt accession | Q86SQ9 |
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| Gene | DHDDS |
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| Organism | Homo sapiens |
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| Length | 333 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (142)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.77
- developmental delay and seizures with or without movement abnormalities · score 0.73
- neurodegenerative disease · score 0.53
- congenital disorder of glycosylation, type Ibb · score 0.42
- congenital disorder of glycosylation · score 0.37
- intellectual disability, autosomal dominant 56 · score 0.37
- undetermined early-onset epileptic encephalopathy · score 0.37
- Retinal dystrophy · score 0.37
- sex hormone-binding globulin measurement · score 0.34
- genetic disorder · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86SQ9-F1 | alphafold | PREDICTED | 94.73 | — |
Amino-acid sequence (333 residues)
MSWIKEGELS LWERFCANII KAGPMPKHIA FIMDGNRRYA KKCQVERQEG HSQGFNKLAE TLRWCLNLGI LEVTVYAFSI ENFKRSKSEV DGLMDLARQK FSRLMEEKEK LQKHGVCIRV LGDLHLLPLD LQELIAQAVQ ATKNYNKCFL NVCFAYTSRH EISNAVREMA WGVEQGLLDP SDISESLLDK CLYTNRSPHP DILIRTSGEV RLSDFLLWQT SHSCLVFQPV LWPEYTFWNL FEAILQFQMN HSVLQKARDM YAEERKRQQL ERDQATVTEQ LLREGLQASG DAQLRRTRLH KLSARREERV QGFLQALELK RADWLARLGT ASA
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