Glutaredoxin-related protein 5, mitochondrial (GLRX5)

About Glutaredoxin-related protein 5, mitochondrial

Glutaredoxin-related protein 5, mitochondrial (GLRX5) is a protein from Homo sapiens identified by UniProt accession Q86SX6, 157 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Glutaredoxin-related protein 5, mitochondrial
UniProt accession	Q86SX6
Gene	GLRX5
Organism	Homo sapiens
Length	157 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

Adult-onset autosomal recessive sideroblastic anemia · score 0.76
sideroblastic anemia 3 · score 0.75
spasticity-ataxia-gait anomalies syndrome · score 0.73
mean corpuscular volume · score 0.48
mean corpuscular hemoglobin · score 0.47
neurodegenerative disease · score 0.44
mean corpuscular hemoglobin concentration · score 0.40
erythrocyte count · score 0.38
red blood cell density measurement · score 0.36
Red cell distribution width · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86SX6-F1	alphafold	PREDICTED	82.34	—

Amino-acid sequence (157 residues)

MSGSLGRAAA ALLRWGRGAG GGGLWGPGVR AAGSGAGGGG SAEQLDALVK KDKVVVFLKG TPEQPQCGFS NAVVQILRLH GVRDYAAYNV LDDPELRQGI KDYSNWPTIP QVYLNGEFVG GCDILLQMHQ NGDLVEELKK LGIHSALLDE KKDQDSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards