C-type lectin domain family 14 member A (CLEC14A)

About C-type lectin domain family 14 member A

C-type lectin domain family 14 member A (CLEC14A) is a protein from Homo sapiens identified by UniProt accession Q86T13, 490 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	C-type lectin domain family 14 member A
UniProt accession	Q86T13
Gene	CLEC14A
Organism	Homo sapiens
Length	490 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.38
neurodegenerative disease · score 0.31
Drugs used in diabetes use measurement · score 0.31
diabetes mellitus · score 0.31
HbA1c measurement · score 0.27
glucose tolerance test · score 0.25
endocrine system disease · score 0.24
5-HIAA measurement · score 0.13
MHPG measurement · score 0.13
anxiety · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86T13-F1	alphafold	PREDICTED	68.52	—

Amino-acid sequence (490 residues)

MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA EEACILRGGA LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR SHCTLENEPL RGFSWLSSDP GGLESDTLQW VEEPQRSCTA RRCAVLQATG GVEPAGWKEM RCHLRANGYL CKYQFEVLCP APRPGAASNL SYRAPFQLHS AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG DVLCPCPGRY LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG SQSTMSTLQM SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF IFVSTAVVVL VILTMTVLGL VKLCFHESPS SQPRKESMGP PGLESDPEPA ALGSSSAHCT NNGVKVGDCD LRDRAEGALL AESPLGSSDA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards