About Transcriptional regulator Kaiso
Transcriptional regulator Kaiso (ZBTB33) is a protein
from Homo sapiens identified by UniProt accession
Q86T24, 672 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Transcriptional regulator Kaiso |
|---|
| UniProt accession | Q86T24 |
|---|
| Gene | ZBTB33 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 672 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (57)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- triple-negative breast cancer · score 0.10
- neoplasm · score 0.09
- chronic myelogenous leukemia · score 0.07
- calf circumference measurement · score 0.05
- cancer · score 0.05
- Bartsocas-Papas syndrome 1 · score 0.04
- acute lymphoblastic leukemia · score 0.03
- non-small cell lung carcinoma · score 0.03
- colitis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86T24-F1 | alphafold | PREDICTED | 54.79 | — |
Amino-acid sequence (672 residues)
MESRKLISAT DIQYSGSLLN SLNEQRGHGL FCDVTVIVED RKFRAHKNIL SASSTYFHQL FSVAGQVVEL SFIRAEIFAE ILNYIYSSKI VRVRSDLLDE LIKSGQLLGV KFIAELGVPL SQVKSISGTA QDGNTEPLPP DSGDKNLVIQ KSKDEAQDNG ATIMPIITES FSLSAEDYEM KKIIVTDSDD DDDDVIFCSE ILPTKETLPS NNTVAQVQSN PGPVAISDVA PSASNNSPPL TNITPTQKLP TPVNQATLSQ TQGSEKLLVS SAPTHLTPNI ILLNQTPLST PPNVSSSLPN HMPSSINLLV QNQQTPNSAI LTGNKANEEE EEEIIDDDDD TISSSPDSAV SNTSLVPQAD TSQNTSFDGS LIQKMQIPTL LQEPLSNSLK ISDIITRNTN DPGVGSKHLM EGQKIITLDT ATEIEGLSTG CKVYANIGED TYDIVIPVKD DPDEGEARLE NEIPKTSGSE MANKRMKVKH DDHYELIVDG RVYYICIVCK RSYVCLTSLR RHFNIHSWEK KYPCRYCEKV FPLAEYRTKH EIHHTGERRY QCLACGKSFI NYQFMSSHIK SVHSQDPSGD SKLYRLHPCR SLQIRQYAYL SDRSSTIPAM KDDGIGYKVD TGKEPPVGTT TSTQNKPMTW EDIFIQQEND SIFKQNVTDG STEFEFIIPE SY
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