Transmembrane protease serine 11B (TMPRSS11B)

About Transmembrane protease serine 11B

Transmembrane protease serine 11B (TMPRSS11B) is a protein from Homo sapiens identified by UniProt accession Q86T26, 416 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Transmembrane protease serine 11B
UniProt accession	Q86T26
Gene	TMPRSS11B
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.21
mean corpuscular hemoglobin concentration · score 0.21
mean corpuscular hemoglobin · score 0.07
esophageal squamous cell carcinoma · score 0.05
oral squamous cell carcinoma · score 0.05
esophageal adenocarcinoma · score 0.04
Barrett's esophagus · score 0.04
breast carcinoma · score 0.03
low density lipoprotein cholesterol measurement · score 0.03
serum metabolite measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86T26-F1	alphafold	PREDICTED	91.54	—

Amino-acid sequence (416 residues)

MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD FHISGVTYND NCENAASQAS TNLSKDIETK MLNAFQNSSI YKEYVKSEVI KLLPNANGSN VQLQLKFKFP PAEGVSMRTK IKAKLHQMLK NNMASWNAVP ASIKLMEISK AASEMLTNNC CGRQVANSII TGNKIVNGKS SLEGAWPWQA SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF GIVVNKPYMT RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTEYIRKIC LPEAKMKLSE NDNVVVTGWG TLYMNGSFPV ILQEDFLKII DNKICNASYA YSGFVTDTML CAGFMSGEAD ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY TRVTSYRNWI TSKTGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards