Protein hinderin (KIAA1328)

About Protein hinderin

Protein hinderin (KIAA1328) is a protein from Homo sapiens identified by UniProt accession Q86T90, 577 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Protein hinderin
UniProt accession	Q86T90
Gene	KIAA1328
Organism	Homo sapiens
Length	577 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

reaction time measurement · score 0.40
risk-taking behaviour · score 0.31
substance abuse · score 0.30
antisocial behaviour measurement · score 0.30
attention deficit hyperactivity disorder · score 0.30
smoking status measurement · score 0.30
waist-hip ratio · score 0.30
hypertrophic cardiomyopathy · score 0.12
heel bone mineral density · score 0.12
electrocardiography · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86T90-F1	alphafold	PREDICTED	60.48	—

Amino-acid sequence (577 residues)

MADVAGPSRP SAAAFWSRDF SDEEQSVVYV PGISAEGNVR SRHKLMSPKA DVKLKTSRVT DASISMESLK GTGDSVDEQN SCRGEIKSAS LKDLCLEDKR RIANLIKELA RVSEEKEVTE ERLKAEQESF EKKIRQLEEQ NELIIKEREA LQLQYRECQE LLSLYQKYLS EQQEKLTMSL SELGAARMQE QQVSSRKSTL QCSSVELDGS YLSIARPQTY YQTKQRPKSA VQDSASESLI AFRNNSLKPV TLHHPKDDLD KIPSETTTCN CESPGRKPAV PTEKMPQEEL HMKECPHLKP TPSQCCGHRL AADRVHDSHP TNMTPQHPKT HPESCSYCRL SWASLVHGGG ALQPIETLKK QISEDRKQQL MLQKMELEIE KERLQHLLAQ QETKLLLKQQ QLHQSRLDYN CLLKSNCDGW LLGTSSSIKK HQDPPNSGEN RKERKTVGFH SHMKDDAQWS CQKKDTCRPQ RGTVTGVRKD ASTSPMPTGS LKDFVTTASP SLQHTTSRYE TSLLDLVQSL SPNSAPKPQR YPSREAGAWN HGTFRLSPLK STRKKMGMHR TPEELEENQI LEDIFFI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards