Leucine zipper protein 2 (LUZP2)

About Leucine zipper protein 2

Leucine zipper protein 2 (LUZP2) is a protein from Homo sapiens identified by UniProt accession Q86TE4, 346 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Leucine zipper protein 2
UniProt accession	Q86TE4
Gene	LUZP2
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.43
self reported educational attainment · score 0.40
drug use measurement · score 0.30
depressive symptom measurement · score 0.30
attention deficit hyperactivity disorder · score 0.30
antisocial behaviour measurement · score 0.30
substance abuse · score 0.30
autism spectrum disorder · score 0.27
intelligence · score 0.27
mathematical ability · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86TE4-F1	alphafold	PREDICTED	72.65	—

Amino-acid sequence (346 residues)

MKFSPAHYLL PLLPALVLST RQDYEELEKQ LKEVFKERST ILRQLTKTSR ELDGIKVNLQ SLKNDEQSAK TDVQKLLELG QKQREEMKSL QEALQNQLKE TSEKAEKHQA TINFLKTEVE RKSKMIRDLQ NENKSLKNKL LSGNKLCGIH AEESKKIQAQ LKELRYGKKD LLFKAQQLTD LEQKLAVAKN ELEKAALDRE SQMKAMKETV QLCLTSVFRD QPPPPLSLIT SNPTRMLLPP RNIASKLPDA AAKSKPQQSA SGNNESSQVE STKEGNPSTT ACDSQDEGRP CSMKHKESPP SNATAETEPI PQKLQMPPCS ECEVKKAPEK PLTSFEGMAA REEKIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards