About TBC1 domain family member 1
TBC1 domain family member 1 (TBC1D1) is a protein
from Homo sapiens identified by UniProt accession
Q86TI0, 1168 residues long.
MolForge cross-references it against 0 known binders and
149 disease associations.
Target properties
| Protein name | TBC1 domain family member 1 |
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| UniProt accession | Q86TI0 |
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| Gene | TBC1D1 |
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| Organism | Homo sapiens |
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| Length | 1168 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (149)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.42
- lymphocyte count · score 0.40
- lymphocyte percentage of leukocytes · score 0.38
- neutrophil percentage of leukocytes · score 0.38
- congenital anomaly of kidney and urinary tract · score 0.37
- neurodegenerative disease · score 0.36
- leukocyte count · score 0.32
- monocyte count · score 0.30
- appendicular lean mass · score 0.29
- cellulitis · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86TI0-F1 | alphafold | PREDICTED | 70.63 | — |
Amino-acid sequence (1168 residues)
MEPITFTARK HLLSNEVSVD FGLQLVGSLP VHSLTTMPML PWVVAEVRRL SRQSTRKEPV TKQVRLCVSP SGLRCEPEPG RSQQWDPLIY SSIFECKPQR VHKLIHNSHD PSYFACLIKE DAVHRQSICY VFKADDQTKV PEIISSIRQA GKIARQEELH CPSEFDDTFS KKFEVLFCGR VTVAHKKAPP ALIDECIEKF NHVSGSRGSE SPRPNPPHAA PTGSQEPVRR PMRKSFSQPG LRSLAFRKEL QDGGLRSSGF FSSFEESDIE NHLISGHNIV QPTDIEENRT MLFTIGQSEV YLISPDTKKI ALEKNFKEIS FCSQGIRHVD HFGFICRESS GGGGFHFVCY VFQCTNEALV DEIMMTLKQA FTVAAVQQTA KAPAQLCEGC PLQSLHKLCE RIEGMNSSKT KLELQKHLTT LTNQEQATIF EEVQKLRPRN EQRENELIIS FLRCLYEEKQ KEHIHIGEMK QTSQMAAENI GSELPPSATR FRLDMLKNKA KRSLTESLES ILSRGNKARG LQEHSISVDL DSSLSSTLSN TSKEPSVCEK EALPISESSF KLLGSSEDLS SDSESHLPEE PAPLSPQQAF RRRANTLSHF PIECQEPPQP ARGSPGVSQR KLMRYHSVST ETPHERKDFE SKANHLGDSG GTPVKTRRHS WRQQIFLRVA TPQKACDSSS RYEDYSELGE LPPRSPLEPV CEDGPFGPPP EEKKRTSREL RELWQKAILQ QILLLRMEKE NQKLQASEND LLNKRLKLDY EEITPCLKEV TTVWEKMLST PGRSKIKFDM EKMHSAVGQG VPRHHRGEIW KFLAEQFHLK HQFPSKQQPK DVPYKELLKQ LTSQQHAILI DLGRTFPTHP YFSAQLGAGQ LSLYNILKAY SLLDQEVGYC QGLSFVAGIL LLHMSEEEAF KMLKFLMFDM GLRKQYRPDM IILQIQMYQL SRLLHDYHRD LYNHLEEHEI GPSLYAAPWF LTMFASQFPL GFVARVFDMI FLQGTEVIFK VALSLLGSHK PLILQHENLE TIVDFIKSTL PNLGLVQMEK TINQVFEMDI AKQLQAYEVE YHVLQEELID SSPLSDNQRM DKLEKTNSSL RKQNLDLLEQ LQVANGRIQS LEATIEKLLS SESKLKQAML TLELERSALL QTVEELRRRS AEPSDREPEC TQPEPTGD
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