Cysteine protease ATG4D (ATG4D)

About Cysteine protease ATG4D

Cysteine protease ATG4D (ATG4D) is a protein from Homo sapiens identified by UniProt accession Q86TL0, 474 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Cysteine protease ATG4D
UniProt accession	Q86TL0
Gene	ATG4D
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

muscle strain · score 0.25
sprain · score 0.25
dislocation · score 0.25
total cholesterol measurement · score 0.21
low density lipoprotein cholesterol measurement · score 0.20
Neurodevelopmental disorder · score 0.19
breast adenocarcinoma · score 0.18
neutrophil count · score 0.10
neutrophil percentage of leukocytes · score 0.09
platelet count · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86TL0-F1	alphafold	PREDICTED	77.41	—

Amino-acid sequence (474 residues)

MNSVSPAAAQ YRSSSPEDAR RRPEARRPRG PRGPDPNGLG PSGASGPALG SPGAGPSEPD EVDKFKAKFL TAWNNVKYGW VVKSRTSFSK ISSIHLCGRR YRFEGEGDIQ RFQRDFVSRL WLTYRRDFPP LPGGCLTSDC GWGCMLRSGQ MMLAQGLLLH FLPRDWTWAE GMGLGPPELS GSASPSRYHG PARWMPPRWA QGAPELEQER RHRQIVSWFA DHPRAPFGLH RLVELGQSSG KKAGDWYGPS LVAHILRKAV ESCSDVTRLV VYVSQDCTVY KADVARLVAR PDPTAEWKSV VILVPVRLGG ETLNPVYVPC VKELLRCELC LGIMGGKPRH SLYFIGYQDD FLLYLDPHYC QPTVDVSQAD FPLESFHCTS PRKMAFAKMD PSCTVGFYAG DRKEFETLCS ELTRVLSSSS ATERYPMFTL AEGHAQDHSL DDLCSQLAQP TLRLPRTGRL LRAKRPSSED FVFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards