About Store-operated calcium entry regulator STIMATE
Store-operated calcium entry regulator STIMATE (STIMATE) is a protein
from Homo sapiens identified by UniProt accession
Q86TL2, 294 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Store-operated calcium entry regulator STIMATE |
|---|
| UniProt accession | Q86TL2 |
|---|
| Gene | STIMATE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 294 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (73)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.21
- HbA1c measurement · score 0.20
- blood protein measurement · score 0.18
- wellbeing measurement · score 0.17
- Central precocious puberty · score 0.15
- body mass index · score 0.14
- glomerular filtration rate · score 0.14
- attention deficit hyperactivity disorder · score 0.14
- self reported educational attainment · score 0.13
- eosinophil count · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86TL2-F1 | alphafold | PREDICTED | 68.91 | — |
Amino-acid sequence (294 residues)
MQGPAGNASR GLPGGPPSTV ASGAGRCESG ALMHSFGIFL QGLLGVVAFS TLMLKRFREP KHERRPWRIW FLDTSKQAIG MLFIHFANVY LADLTEEDPC SLYLINFLLD ATVGMLLIYV GVRAVSVLVE WQQWESLRFG EYGDPLQCGA WVGQCALYIV IMIFEKSVVF IVLLILQWKK VALLNPIENP DLKLAIVMLI VPFFVNALMF WVVDNFLMRK GKTKAKLEER GANQDSRNGS KVRYRRAASH EESESEILIS ADDEMEESDV EEDLRRLTPL KPVKKKKHRF GLPV
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