About E3 ubiquitin-protein ligase synoviolin
E3 ubiquitin-protein ligase synoviolin (SYVN1) is a protein
from Homo sapiens identified by UniProt accession
Q86TM6, 617 residues long.
MolForge cross-references it against 0 known binders and
161 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase synoviolin |
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| UniProt accession | Q86TM6 |
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| Gene | SYVN1 |
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| Organism | Homo sapiens |
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| Length | 617 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (161)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- holoprosencephaly · score 0.46
- lysosomal storage disease · score 0.37
- breast adenocarcinoma · score 0.18
- Seizure · score 0.15
- encephalomalacia · score 0.15
- Delayed speech and language development · score 0.15
- hypospadias · score 0.15
- periventricular leukomalacia · score 0.15
- Hypotonia · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86TM6-F1 | alphafold | PREDICTED | 72.16 | — |
Amino-acid sequence (617 residues)
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA FVLVFLLGKV MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL LFLKCFHWLA EDRVDFMERS PNISWLFHCR IVSLMFLLGI LDFLFVSHAY HSILTRGASV QLVFGFEYAI LMTMVLTIFI KYVLHSVDLQ SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF PLFAIRPMYL AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD QGPPPAPHPP PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS GEAVAPPSTS AAALSRPSGA ATTTAAGTSA TAASATASGP GSGSAPEAGP APGFPFPPPW MGMPLPPPFA FPPMPVPPAG FAGLTPEELR ALEGHERQHL EARLQSLRNI HTLLDAAMLQ INQYLTVLAS LGPPRPATSV NSTEETATTV VAAASSTSIP SSEATTPTPG ASPPAPEMER PPAPESVGTE EMPEDGEPDA AELRRRRLQK LESPVAH
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