About Actin-histidine N-methyltransferase
Actin-histidine N-methyltransferase (SETD3) is a protein
from Homo sapiens identified by UniProt accession
Q86TU7, 594 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Actin-histidine N-methyltransferase |
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| UniProt accession | Q86TU7 |
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| Gene | SETD3 |
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| Organism | Homo sapiens |
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| Length | 594 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.24
- eosinophil count · score 0.21
- PHF-tau measurement · score 0.12
- clear cell renal carcinoma · score 0.10
- systolic blood pressure · score 0.08
- breast cancer · score 0.07
- sodium measurement · score 0.07
- viral disease · score 0.06
- neoplasm · score 0.06
- hepatocellular carcinoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86TU7-F1 | alphafold | PREDICTED | 86.36 | — |
Amino-acid sequence (594 residues)
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PGPGKEWEEY VQIRTLVEKI RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP SEYDTPLYFE EDEVRYLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKDSFT YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL QDFRAGEQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA GIPTSSVFAL HFTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNSEFPVSW DNEVKLWTFL EDRASLLLKT YKTTIEEDKS VLKNHDLSVR AKMAIKLRLG EKEILEKAVK SAAVNREYYR QQMEEKAPLP KYEESNLGLL ESSVGDSRLP LVLRNLEEEA GVQDALNIRE AISKAKATEN GLVNGENSIP NGTRSENESL NQESKRAVED AKGSSSDSTA GVKE
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