About Tetratricopeptide repeat protein 7B
Tetratricopeptide repeat protein 7B (TTC7B) is a protein
from Homo sapiens identified by UniProt accession
Q86TV6, 843 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Tetratricopeptide repeat protein 7B |
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| UniProt accession | Q86TV6 |
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| Gene | TTC7B |
|---|
| Organism | Homo sapiens |
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| Length | 843 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- FEV/FVC ratio · score 0.35
- schizophrenia · score 0.29
- gut microbiome measurement · score 0.25
- neurofibrillary tangles measurement · score 0.20
- body height · score 0.13
- head and neck squamous cell carcinoma · score 0.07
- Griscelli syndrome type 3 · score 0.06
- metabolite measurement · score 0.06
- drug use measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86TV6-F1 | alphafold | PREDICTED | 84.99 | — |
Amino-acid sequence (843 residues)
MATKKAGSRL ETEIERCRSE CQWERIPELV KQLSAKLIAN DDMAELLLGE SKLEQYLKEH PLRQGASPRG PKPQLTEVRK HLTAALDRGN LKSEFLQESN LIMAKLNYVE GDYKEALNIY ARVGLDDLPL TAVPPYRLRV IAEAYATKGL CLEKLPISSS TSNLHVDREQ DVITCYEKAG DIALLYLQEI ERVILSNIQN RSPKPGPAPH DQELGFFLET GLQRAHVLYF KNGNLTRGVG RFRELLRAVE TRTTQNLRMT IARQLAEILL RGMCEQSYWN PLEDPPCQSP LDDPLRKGAN TKTYTLTRRA RVYSGENIFC PQENTEEALL LLLISESMAN RDAVLSRIPE HKSDRLISLQ SASVVYDLLT IALGRRGQYE MLSECLERAM KFAFEEFHLW YQFALSLMAA GKSARAVKVL KECIRLKPDD ATIPLLAAKL CMGSLHWLEE AEKFAKTVVD VGEKTSEFKA KGYLALGLTY SLQATDASLR GMQEVLQRKA LLAFQRAHSL SPTDHQAAFY LALQLAISRQ IPEALGYVRQ ALQLQGDDAN SLHLLALLLS AQKHYHDALN IIDMALSEYP ENFILLFSKV KLQSLCRGPD EALLTCKHML QIWKSCYNLT NPSDSGRGSS LLDRTIADRR QLNTITLPDF SDPETGSVHA TSVAASRVEQ ALSEVASSLQ SSAPKQGPLH PWMTLAQIWL HAAEVYIGIG KPAEATACTQ EAANLFPMSH NVLYMRGQIA ELRGSMDEAR RWYEEALAIS PTHVKSMQRL ALILHQLGRY SLAEKILRDA VQVNSTAHEV WNGLGEVLQA QGNDAAATEC FLTALELEAS SPAVPFTIIP RVL
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