About AarF domain-containing protein kinase 1
AarF domain-containing protein kinase 1 (ADCK1) is a protein
from Homo sapiens identified by UniProt accession
Q86TW2, 530 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | AarF domain-containing protein kinase 1 |
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| UniProt accession | Q86TW2 |
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| Gene | ADCK1 |
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| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (28)
Diseases linked to this target (Open Targets).
- resting heart rate · score 0.29
- body height · score 0.29
- neurodegenerative disease · score 0.28
- diet measurement · score 0.26
- schizophrenia symptom severity measurement · score 0.24
- age at menarche · score 0.18
- sleep duration · score 0.13
- osteosarcoma · score 0.07
- neoplasm · score 0.05
- Hepatitis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86TW2-F1 | alphafold | PREDICTED | 83.69 | — |
Amino-acid sequence (530 residues)
MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS YDYLTSLKSV PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF IKVGQHLGAL DYLLPEEYTS TLKVLHSQAP QSSMQEIRQV IREDLGKEIH DLFQSFDDTP LGTASLAQVH KAVLHDGRTV AVKVQHPKVR AQSSKDILLM EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA EKVSQMLRHF DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR LNYCHLWQSL IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI SQAPVTATED LEIRNNAANY LPQISHLLNH VPRQMLLILK TNDLLRGIEA ALGTRASASS FLNMSRCCIR ALAEHKKKNT CSFFRRTQIS FSEAFNLWQI NLHELILRVK GLKLADRVLA LICWLFPAPL
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