Acyl-coenzyme A thioesterase 1 (ACOT1)

About Acyl-coenzyme A thioesterase 1

Acyl-coenzyme A thioesterase 1 (ACOT1) is a protein from Homo sapiens identified by UniProt accession Q86TX2, 421 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Acyl-coenzyme A thioesterase 1
UniProt accession	Q86TX2
Gene	ACOT1
Organism	Homo sapiens
Length	421 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

Generalized hypotonia · score 0.33
blood protein measurement · score 0.16
blood metabolite measurement · score 0.11
platelet count · score 0.11
phosphatidylcholine measurement · score 0.07
Blackfan-Diamond anemia · score 0.07
alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
hemoglobin D disease · score 0.06
Heinz body anemia · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86TX2-F1	alphafold	PREDICTED	96.46	—

Amino-acid sequence (421 residues)

MAATLILEPA GRCCWDEPVR IAVRGLAPEQ PVTLRASLRD EKGALFQAHA RYRADTLGEL DLERAPALGG SFAGLEPMGL LWALEPEKPL VRLVKRDVRT PLAVELEVLD GHDPDPGRLL CRVRHERYFL PPGVRREPVR AGRVRGTLFL PPEPGPFPGI VDMFGTGGGL LEYRASLLAG KGFAVMALAY YNYEDLPKTM ETLHLEYFEE AVNYLLSHPE VKGPGVGLLG ISKGGELCLS MASFLKGITA AVVINGSVAN VGGTLRYKGE TLPPVGVNRN RIKVTKDGYA DIVDVLNSPL EGPDQKSFIP VERAESTFLF LVGQDDHNWK SEFYANEACK RLQAHGRRKP QIICYPETGH YIEPPYFPLC RASLHALVGS PIIWGGEPRA HAMAQVDAWK QLQTFFHKHL GGHEGTIPSK V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards