About Armadillo-like helical domain-containing protein 4
Armadillo-like helical domain-containing protein 4 (ARMH4) is a protein
from Homo sapiens identified by UniProt accession
Q86TY3, 774 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Armadillo-like helical domain-containing protein 4 |
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| UniProt accession | Q86TY3 |
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| Gene | ARMH4 |
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| Organism | Homo sapiens |
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| Length | 774 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (55)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.43
- mean corpuscular volume · score 0.39
- Red cell distribution width · score 0.37
- alcohol consumption measurement · score 0.35
- mean corpuscular hemoglobin · score 0.32
- mean reticulocyte volume · score 0.30
- BMI-adjusted waist-hip ratio · score 0.29
- waist-hip ratio · score 0.29
- erythrocyte count · score 0.28
- red blood cell density measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86TY3-F1 | alphafold | PREDICTED | 43.72 | — |
Amino-acid sequence (774 residues)
MRGPIVLHIC LAFCSLLLFS VATQCLAFPK IERRREIAHV HAEKGQSDKM NTDDLENSSV TSKQTPQLVV SEDPMMMSAV PSATSLNKAF SINKETQPGQ AGLMQTERPG VSTPTESGVP SAEEVFGSSQ PERISPESGL AKAMLTIAIT ATPSLTVDEK EELLTSTNFQ PIVEEITETT KGFLKYMDNQ SFATESQEGV GLGHSPSSYV NTKEMLTTNP KTEKFEADTD HRTTSFPGAE STAGSEPGSL TPDKEKPSQM TADNTQAAAT KQPLETSEYT LSVEPETDSL LGAPEVTVSV STAVPAASAL SDEWDDTKLE SVSRIRTPKL GDNEETQVRT EMSQTAQVSH EGMEGGQPWT EAAQVALGLP EGETHTGTAL LIAHGNERSP AFTDQSSFTP TSLMEDMKVS IVNLLQSTGD FTESTKENDA LFFLETTVSV SVYESEADQL LGNTMKDIIT QEMTTAVQEP DATLSMVTQE QVATLELIRD SGKTEEEKED PSPVSDVPGV TQLSRRWEPL ATTISTTVVP LSFEVTPTVE EQMDTVTGPN EEFTPVLGSP VTPPGIMVGE PSISPALPAL EASSERRTVV PSITRVNTAA SYGLDQLESE EGQEDEDEED EEDEDEEEED EEEDEEDKDA DSLDEGLDGD TELPGFTLPG ITSQEPGLEE GNMDLLEGAT YQVPDALEWE QQNQGLVRSW MEKLKDKAGY MSGMLVPVGV GIAGALFILG ALYSIKVMNR RRRNGFKRHK RKQREFNSMQ DRVMLLADSS EDEF
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