Tetratricopeptide repeat protein 6 (TTC6)

About Tetratricopeptide repeat protein 6

Tetratricopeptide repeat protein 6 (TTC6) is a protein from Homo sapiens identified by UniProt accession Q86TZ1, 520 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Tetratricopeptide repeat protein 6
UniProt accession	Q86TZ1
Gene	TTC6
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

allergic disease · score 0.37
prostate carcinoma · score 0.31
allergic rhinitis · score 0.30
neurodegenerative disease · score 0.27
gut microbiome measurement · score 0.27
eosinophil count · score 0.23
Parkinson disease · score 0.18
urate measurement · score 0.18
eosinophil percentage of leukocytes · score 0.18
Meckel syndrome · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86TZ1-F1	alphafold	PREDICTED	91.83	—

Amino-acid sequence (520 residues)

MMKYYDLAKF TIYQIAEMDK GLSELSPMQQ ALIYSFCENH DKAIEVLDGI SWNRAEMTMC ALLAKVQMKA KRTKEAVEVL KKALDAISHS DKGPDATAIS ADCLYNLGLC YMEEGNLQMT YKLAITDLTT AISMDKNSYT AFYNRALCYT KIRELQMALT DYGIVLLLDA TETVKLNTFL NRGLIYVELG QYGFALEDFK QAALISRTNG SLCHATAMCH HRINEFEEAV NFFTWALKIN PCFLDAYVGR GNSYMEYGHD EATKQAQKDF LKALHINPAY IKARISFGYN LQAQGKFQKA WNHFTIAIDT DPKNYLAYEG RAVVCLQMGN NFAAMQDINA AMKISTTAEF LTNRGVIHEF MGHKQNAMKD YQDAITLNPK YSLAYFNAGN IYFHHRQFSQ ASDYFSKALK FDPENEYVLM NRAITNTILK KYEEAKEDFA NVIESCPFWA AVYFNRAHFY YCLKQYELAE EDLNKALSLK PNDALVYNFR AKVRGKIGLI EEAMADYNQA LDLEDYASVI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards