About 60 kDa lysophospholipase
60 kDa lysophospholipase (ASPG) is a protein
from Homo sapiens identified by UniProt accession
Q86U10, 573 residues long.
MolForge cross-references it against 0 known binders and
230 disease associations.
Target properties
| Protein name | 60 kDa lysophospholipase |
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| UniProt accession | Q86U10 |
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| Gene | ASPG |
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| Organism | Homo sapiens |
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| Length | 573 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (230)
Diseases linked to this target (Open Targets).
- amino acid measurement · score 0.49
- serum metabolite measurement · score 0.46
- asparagine measurement · score 0.42
- hair colour measurement · score 0.31
- glutamine measurement · score 0.31
- serine measurement · score 0.31
- histidine measurement · score 0.31
- lysine measurement · score 0.31
- methionine measurement · score 0.31
- threonine measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86U10-F1 | alphafold | PREDICTED | 89.72 | — |
Amino-acid sequence (573 residues)
MARAVGPERR LLAVYTGGTI GMRSELGVLV PGTGLAAILR TLPMFHDEEH ARARGLSEDT LVLPPASRNQ RILYTVLECQ PLFDSSDMTI AEWVCLAQTI KRHYEQYHGF VVIHGTDTMA FAASMLSFML ENLQKTVILT GAQVPIHALW SDGRENLLGA LLMAGQYVIP EVCLFFQNQL FRGNRATKVD ARRFAAFCSP NLLPLATVGA DITINRELVR KVDGKAGLVV HSSMEQDVGL LRLYPGIPAA LVRAFLQPPL KGVVMETFGS GNGPTKPDLL QELRVATERG LVIVNCTHCL QGAVTTDYAA GMAMAGAGVI SGFDMTSEAA LAKLSYVLGQ PGLSLDVRKE LLTKDLRGEM TPPSVEERRP SLQGNTLGGG VSWLLSLSGS QEADALRNAL VPSLACAAAH AGDVEALQAL VELGSDLGLV DFNGQTPLHA AARGGHTEAV TMLLQRGVDV NTRDTDGFSP LLLAVRGRHP GVIGLLREAG ASLSTQELEE AGTELCRLAY RADLEGLQVW WQAGADLGQP GYDGHSALHV AEAAGNLAVV AFLQSLEGAV GAQAPCPEVL PGV
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