About Iron-sulfur cluster assembly 2 homolog, mitochondrial
Iron-sulfur cluster assembly 2 homolog, mitochondrial (ISCA2) is a protein
from Homo sapiens identified by UniProt accession
Q86U28, 154 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Iron-sulfur cluster assembly 2 homolog, mitochondrial |
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| UniProt accession | Q86U28 |
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| Gene | ISCA2 |
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| Organism | Homo sapiens |
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| Length | 154 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- multiple mitochondrial dysfunctions syndrome 4 · score 0.76
- optic atrophy · score 0.43
- neurodegenerative disease · score 0.42
- genetic disorder · score 0.40
- Fatal multiple mitochondrial dysfunction syndrome · score 0.37
- mitochondrial disease · score 0.37
- Optic atrophy · score 0.37
- fatal multiple mitochondrial dysfunctions syndrome · score 0.27
- Fatal multiple mitochondrial dysfunction syndrome type 2 · score 0.27
- Death in infancy · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86U28-F1 | alphafold | PREDICTED | 76.99 | — |
Amino-acid sequence (154 residues)
MAAAWGSSLT AATQRAVTPW PRGRLLTASL GPQARREASS SSPEAGEGQI RLTDSCVQRL LEITEGSEFL RLQVEGGGCS GFQYKFSLDT VINPDDRVFE QGGARVVVDS DSLAFVKGAQ VDFSQELIRS SFQVLNNPQA QQGCSCGSSF SIKL
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