About N(6)-adenosine-methyltransferase catalytic subunit METTL3
N(6)-adenosine-methyltransferase catalytic subunit METTL3 (METTL3) is a protein
from Homo sapiens identified by UniProt accession
Q86U44, 580 residues long.
MolForge cross-references it against 0 known binders and
440 disease associations.
Target properties
| Protein name | N(6)-adenosine-methyltransferase catalytic subunit METTL3 |
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| UniProt accession | Q86U44 |
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| Gene | METTL3 |
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| Organism | Homo sapiens |
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| Length | 580 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (440)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- fat body mass · score 0.13
- neoplasm · score 0.12
- hepatocellular carcinoma · score 0.12
- non-small cell lung carcinoma · score 0.12
- esophageal squamous cell carcinoma · score 0.12
- oral squamous cell carcinoma · score 0.11
- breast cancer · score 0.11
- acute myeloid leukemia · score 0.11
- cancer · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86U44-F1 | alphafold | PREDICTED | 75.38 | — |
Amino-acid sequence (580 residues)
MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSGG PKPSTASAVP ELATDPELEK KLLHHLSDLA LTLPTDAVSI CLAISTPDAP ATQDGVESLL QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAMMGAV AEKKGPGEVA GTVTGQKRRA EQDSTTVAAF ASSLVSGLNS SASEPAKEPA KKSRKHAASD VDLEIESLLN QQSTKEQQSK KVSQEILELL NTTTAKEQSI VEKFRSRGRA QVQEFCDYGT KEECMKASDA DRPCRKLHFR RIINKHTDES LGDCSFLNTC FHMDTCKYVH YEIDACMDSE APGSKDHTPS QELALTQSVG GDSSADRLFP PQWICCDIRY LDVSILGKFA VVMADPPWDI HMELPYGTLT DDEMRRLNIP VLQDDGFLFL WVTGRAMELG RECLNLWGYE RVDEIIWVKT NQLQRIIRTG RTGHWLNHGK EHCLVGVKGN PQGFNQGLDC DVIVAEVRST SHKPDEIYGM IERLSPGTRK IELFGRPHNV QPNWITLGNQ LDGIHLLDPD VVARFKQRYP DGIISKPKNL
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