LIM domain-binding protein 1 (LDB1)

About LIM domain-binding protein 1

LIM domain-binding protein 1 (LDB1) is a protein from Homo sapiens identified by UniProt accession Q86U70, 411 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	LIM domain-binding protein 1
UniProt accession	Q86U70
Gene	LDB1
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
medulloblastoma · score 0.46
pilocytic astrocytoma · score 0.36
acute myeloid leukemia · score 0.26
breast carcinoma · score 0.21
autism spectrum disorder · score 0.09
IGF-1 measurement · score 0.07
mathematical ability · score 0.07
self reported educational attainment · score 0.05
neoplasm · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86U70-F1	alphafold	PREDICTED	70.43	—

Amino-acid sequence (411 residues)

MSVGCACPGC SSKSFKLYSP KEPPNGNAFP PFHPGTMLDR DVGPTPMYPP TYLEPGIGRH TPYGNQTDYR IFELNKRLQN WTEECDNLWW DAFTTEFFED DAMLTITFCL EDGPKRYTIG RTLIPRYFRS IFEGGATELY YVLKHPKEAF HSNFVSLDCD QGSMVTQHGK PMFTQVCVEG RLYLEFMFDD MMRIKTWHFS IRQHRELIPR SILAMHAQDP QMLDQLSKNI TRCGLSNSTL NYLRLCVILE PMQELMSRHK TYSLSPRDCL KTCLFQKWQR MVAPPAEPTR QQPSKRRKRK MSGGSTMSSG GGNTNNSNSK KKSPASTFAL SSQVPDVMVV GEPTLMGGEF GDEDERLITR LENTQFDAAN GIDDEDSFNN SPALGANSPW NSKPPSSQES KSENPTSQAS Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards