About Threonylcarbamoyl-AMP synthase
Threonylcarbamoyl-AMP synthase (YRDC) is a protein
from Homo sapiens identified by UniProt accession
Q86U90, 279 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Threonylcarbamoyl-AMP synthase |
|---|
| UniProt accession | Q86U90 |
|---|
| Gene | YRDC |
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| Organism | Homo sapiens |
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| Length | 279 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (45)
Diseases linked to this target (Open Targets).
- Galloway-Mowat syndrome 10 · score 0.57
- Galloway-Mowat syndrome · score 0.56
- pulse pressure measurement · score 0.10
- eosinophil percentage of leukocytes · score 0.08
- non-small cell lung carcinoma · score 0.08
- rheumatoid arthritis · score 0.08
- mathematical ability · score 0.07
- eosinophil count · score 0.07
- hepatocellular carcinoma · score 0.06
- Red cell distribution width · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86U90-F1 | alphafold | PREDICTED | 82.57 | — |
Amino-acid sequence (279 residues)
MSPARRCRGM RAAVAASVGL SEGPAGSRSG RLFRPPSPAP AAPGARLLRL PGSGAVQAAS PERAGWTEAL RAAVAELRAG AVVAVPTDTL YGLACAASCS AALRAVYRLK GRSEAKPLAV CLGRVADVYR YCRVRVPEGL LKDLLPGPVT LVMERSEELN KDLNPFTPLV GIRIPDHAFM QDLAQMFEGP LALTSANLSS QASSLNVEEF QDLWPQLSLV IDGGQIGDGQ SPECRLGSTV VDLSVPGKFG IIRPGCALES TTAILQQKYG LLPSHASYL
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