Transmembrane protein 135 (TMEM135)

About Transmembrane protein 135

Transmembrane protein 135 (TMEM135) is a protein from Homo sapiens identified by UniProt accession Q86UB9, 458 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Transmembrane protein 135
UniProt accession	Q86UB9
Gene	TMEM135
Organism	Homo sapiens
Length	458 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.43
bone quantitative ultrasound measurement · score 0.41
bone density · score 0.39
electrocardiography · score 0.37
alkaline phosphatase measurement · score 0.33
bone fracture · score 0.29
cup-to-disc ratio measurement · score 0.27
velocity of sound measurement · score 0.23
spine bone mineral density · score 0.23
ulna fracture · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UB9-F1	alphafold	PREDICTED	86.53	—

Amino-acid sequence (458 residues)

MAALSKSIPH NCYEIGHTWH PSCRVSFLQI TGGALEESLK IYAPLYLIAA ILRKRKLDYY LHKLLPEILQ SASFLTANGA LYMAFFCILR KILGKFYSWT PGFGAALPAS YVAILIERKS RRGLLTIYMA NLATETLFRM GVARGTITTL RNGEVLLFCI TAAMYMFFFR CKDGLKGFTF SALRFIVGKE EIPTHSFSPE AAYAKVEQKR EQHEEKPGRM NMIGLVRKFV DSICKHGPRH RCCKHYEDNC ISYCIKGFIR MFSVGYLIQC CLRIPSAFRH LFTQPSRLLS LFYNKENFQL GAFLGSFVSI YKGTSCFLRW IRNLDDELHA IIAGFLAGIS MMFYKSTTIS MYLASKLVET MYFKGIEAGK VPYFPHADTI IYSISTAICF QAAVMEVQTL RPSYWKFLLR LTKGKFAVMN RKVLDVFGTG ASKHFQDFIP RLDPRYTTVT PELPTEFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards