Suppressor APC domain-containing protein 2 (SAPCD2)

About Suppressor APC domain-containing protein 2

Suppressor APC domain-containing protein 2 (SAPCD2) is a protein from Homo sapiens identified by UniProt accession Q86UD0, 394 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Suppressor APC domain-containing protein 2
UniProt accession	Q86UD0
Gene	SAPCD2
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

high density lipoprotein cholesterol measurement · score 0.20
aspartate aminotransferase measurement · score 0.19
colorectal carcinoma · score 0.07
platelet count · score 0.07
leukocyte count · score 0.06
neoplasm · score 0.05
non-small cell lung carcinoma · score 0.04
monocyte count · score 0.03
melanoma · score 0.03
lung adenocarcinoma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UD0-F1	alphafold	PREDICTED	67.95	—

Amino-acid sequence (394 residues)

MAGAAMAERG RVPPPAPAPS TEGLPRAFLQ SLRTLFDILD DRRRGCVHLR EIESRWQGTD ARELPRGVLE GLRQVAPASG YLTFERFVAG LRTSLLSADG GPRDPTRAPA RPGDQPPPPP QRLVFAPADE PRTVLERKPL PLGVRAPLAG PSAAARSPEQ LCAPAEAAPC PAEPERSQSA ALEPSSSADA GAVACRALEA DSGDARRAPR ARGERRRHTI ASGVDCGLLK QMKELEQEKE VLLQGLEMMA RGRDWYQQQL QRVQERQRRL GQSRASADFG AAGSPRPLGR LLPKVQEVAR CLGELLAAAC ASRALPPSSS GPPCPALTST SPPVWQQQTI LMLKEQNRLL TQEVTEKSER ITQLEQEKSA LIKQLFEARA LSQQDGGPLD STFI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards