E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)

About E3 ubiquitin-protein ligase MARCHF3

E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) is a protein from Homo sapiens identified by UniProt accession Q86UD3, 253 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase MARCHF3
UniProt accession	Q86UD3
Gene	MARCHF3
Organism	Homo sapiens
Length	253 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UD3-F1	alphafold	PREDICTED	70.44	—

Amino-acid sequence (253 residues)

MTTSRCSHLP EVLPDCTSSA APVVKTVEDC GSLVNGQPQY VMQVSAKDGQ LLSTVVRTLA TQSPFNDRPM CRICHEGSSQ EDLLSPCECT GTLGTIHRSC LEHWLSSSNT SYCELCHFRF AVERKPRPLV EWLRNPGPQH EKRTLFGDMV CFLFITPLAT ISGWLCLRGA VDHLHFSSRL EAVGLIALTV ALFTIYLFWT LVSFRYHCRL YNEWRRTNQR VILLIPKSVN VPSNQPSLLG LHSVKRNSKE TVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards