About Sodium/hydrogen exchanger 9B2
Sodium/hydrogen exchanger 9B2 (SLC9B2) is a protein
from Homo sapiens identified by UniProt accession
Q86UD5, 537 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Sodium/hydrogen exchanger 9B2 |
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| UniProt accession | Q86UD5 |
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| Gene | SLC9B2 |
|---|
| Organism | Homo sapiens |
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| Length | 537 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (96)
Diseases linked to this target (Open Targets).
- diastolic blood pressure · score 0.27
- type 2 diabetes mellitus · score 0.18
- multiple sclerosis · score 0.18
- glioblastoma multiforme · score 0.18
- Alzheimer disease · score 0.17
- lysosomal storage disease · score 0.17
- neurodegenerative disease · score 0.17
- Parkinson disease · score 0.17
- glomerular filtration rate · score 0.16
- head and neck squamous cell carcinoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UD5-F1 | alphafold | PREDICTED | 78.60 | — |
Amino-acid sequence (537 residues)
MGDEDKRITY EDSEPSTGMN YTPSMHQEAQ EETVMKLKGI DANEPTEGSI LLKSSEKKLQ ETPTEANHVQ RLRQMLACPP HGLLDRVITN VTIIVLLWAV VWSITGSECL PGGNLFGIII LFYCAIIGGK LLGLIKLPTL PPLPSLLGML LAGFLIRNIP VINDNVQIKH KWSSSLRSIA LSIILVRAGL GLDSKALKKL KGVCVRLSMG PCIVEACTSA LLAHYLLGLP WQWGFILGFV LGAVSPAVVV PSMLLLQGGG YGVEKGVPTL LMAAGSFDDI LAITGFNTCL GIAFSTGSTV FNVLRGVLEV VIGVATGSVL GFFIQYFPSR DQDKLVCKRT FLVLGLSVLA VFSSVHFGFP GSGGLCTLVM AFLAGMGWTS EKAEVEKIIA VAWDIFQPLL FGLIGAEVSI ASLRPETVGL CVATVGIAVL IRILTTFLMV CFAGFNLKEK IFISFAWLPK ATVQAAIGSV ALDTARSHGE KQLEDYGMDV LTVAFLSILI TAPIGSLLIG LLGPRLLQKV EHQNKDEEVQ GETSVQV
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