About Zinc finger protein 546
Zinc finger protein 546 (ZNF546) is a protein
from Homo sapiens identified by UniProt accession
Q86UE3, 836 residues long.
MolForge cross-references it against 0 known binders and
6 disease associations.
Target properties
| Protein name | Zinc finger protein 546 |
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| UniProt accession | Q86UE3 |
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| Gene | ZNF546 |
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| Organism | Homo sapiens |
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| Length | 836 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (6)
Diseases linked to this target (Open Targets).
- Hashimoto's thyroiditis · score 0.03
- hypothyroidism · score 0.02
- neoplasm · score 0.00
- kidney disease · score 0.00
- hepatocellular carcinoma · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q86UE3-F1 | alphafold | PREDICTED | 73.77 | — |
Amino-acid sequence (836 residues)
MQVDPPLHGP PNDFLIFQII PLHSLSIMPR FLWILCFSME ETQGELTSSC GSKTMANVSL AFRDVSIDLS QEEWECLDAV QRDLYKDVML ENYSNLVSLG YTIPKPDVIT LLEQEKEPWI VMREGTRNWF TDLEYKYITK NLLSEKNVCK IYLSQLQTGE KSKNTIHEDT IFRNGLQCKH EFERQERHQM GCVSQMLIQK QISHPLHPKI HAREKSYECK ECRKAFRQQS YLIQHLRIHT GERPYKCMEC GKAFCRVGDL RVHHTIHAGE RPYECKECGK AFRLHYHLTE HQRIHSGVKP YECKECGKAF SRVRDLRVHQ TIHAGERPYE CKECGKAFRL HYQLTEHQRI HTGERPYECK VCGKTFRVQR HISQHQKIHT GVKPYKCNEC GKAFSHGSYL VQHQKIHTGE KPYECKECGK SFSFHAELAR HRRIHTGEKP YECRECGKAF RLQTELTRHH RTHTGEKPYE CKECGKAFIC GYQLTLHLRT HTGEIPYECK ECGKTFSSRY HLTQHYRIHT GEKPYICNEC GKAFRLQGEL TRHHRIHTCE KPYECKECGK AFIHSNQFIS HQRIHTSEST YICKECGKIF SRRYNLTQHF KIHTGEKPYI CNECGKAFRF QTELTQHHRI HTGEKPYKCT ECGKAFIRST HLTQHHRIHT GEKPYECTEC GKTFSRHYHL TQHHRGHTGE KPYICNECGN AFICSYRLTL HQRIHTGELP YECKECGKTF SRRYHLTQHF RLHTGEKPYS CKECGNAFRL QAELTRHHIV HTGEKPYKCK ECGKAFSVNS ELTRHHRIHT GEKPYQCKEC GKAFIRSDQL TLHQRNHISE EVLCIM
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