Protein LYRIC (MTDH)

About Protein LYRIC

Protein LYRIC (MTDH) is a protein from Homo sapiens identified by UniProt accession Q86UE4, 582 residues long. MolForge cross-references it against 0 known binders and 237 disease associations.

Target properties

Protein name	Protein LYRIC
UniProt accession	Q86UE4
Gene	MTDH
Organism	Homo sapiens
Length	582 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (237)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.46
mean corpuscular hemoglobin concentration · score 0.39
mean corpuscular hemoglobin · score 0.39
mean corpuscular volume · score 0.37
hemoglobin measurement · score 0.27
reticulocyte measurement · score 0.26
nicotine metabolite ratio · score 0.24
genetic disorder · score 0.12
hepatocellular carcinoma · score 0.12
neoplasm · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q86UE4-F1	alphafold	PREDICTED	51.71	—

Amino-acid sequence (582 residues)

MAARSWQDEL AQQAEEGSAR LREMLSVGLG FLRTELGLDL GLEPKRYPGW VILVGTGALG LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAAVPAAAP DDLALLKNLR SEEQKKKNRK KLSEKPKPNG RTVEVAEGEA VRTPQSVTAK QPPEIDKKNE KSKKNKKKSK SDAKAVQNSS RHDGKEVDEG AWETKISHRE KRQQRKRDKV LTDSGSLDST IPGIENTITV TTEQLTTASF PVGSKKNKGD SHLNVQVSNF KSGKGDSTLQ VSSGLNENLT VNGGGWNEKS VKLSSQISAG EEKWNSVSPA SAGKRKTEPS AWSQDTGDAN TNGKDWGRSW SDRSIFSGIG STAEPVSQST TSDYQWDVSR NQPYIDDEWS GLNGLSSADP NSDWNAPAEE WGNWVDEERA SLLKSQEPIP DDQKVSDDDK EKGEGALPTG KSKKKKKKKK KQGEDNSTAQ DTEELEKEIR EDLPVNTSKT RPKQEKAFSL KTISTSDPAE VLVKNSQPIK TLPPATSTEP SVILSKSDSD KSSSQVPPIL QETDKSKSNT KQNSVPPSQT KSETSWESPK QIKKKKKARR ET

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards